Evidence map›Paper›PMID 38718220›Full record

ArticleACS nano2024

Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood-Brain Barrier.

Zih-An Chen, Cheng-Hsun Wu, Si-Han Wu, Chiung-Yin Huang, Chung-Yuan Mou, Kuo-Chen Wei, Yun Yen, I-Ting Chien, Sabiha Runa, Yi-Ping Chen and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
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  4. Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects.Advanced materials (Deerfield Beach, Fla.) · 2026
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  15. The Role of CRISPR and Its Therapeutic Applications in Glioblastoma.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zih-An ChenDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Cheng-Hsun WuNano Targeting & Therapy Biopharma Inc., Taipei 10087, Taiwan.
Si-Han WuGraduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-2586-7538
Chiung-Yin HuangNeuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Chung-Yuan MouDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-7060-9899
Kuo-Chen WeiNeuroscience Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Yun YenCenter for Cancer Translational Research, Tzu Chi University, Hualien 970374, Taiwan.ORCID 0000-0003-0815-412X
I-Ting ChienDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Sabiha RunaDepartment of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Yi-Ping ChenGraduate Institute of Nanomedicine and Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-5443-2632
Peilin ChenResearch Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0003-4154-0487

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain tumor therapy. However, the blood-brain barrier (BBB) often presents a formidable obstacle to efficient drug delivery. This study introduces a ligand-free PEGylated MSN variant (RMSN

Indexed as

Blood-Brain BarrierDoxorubicinDrug CarriersNanoparticlesSilicon DioxideAnimalsAntibiotics, AntineoplasticBrain NeoplasmsCell Line, TumorGliomaHumansLigandsMiceParticle SizePolyethylene GlycolsPorosityAntibiotics, AntineoplasticDoxorubicinDrug CarriersLigandsPolyethylene GlycolsSilicon Dioxideblood−brain barrierbrain tumordoxorubicinmesoporous silica nanoparticlesprotein coronathe enhanced permeability and retention effect

Identifiers

PMID38718220
PMCPMC11112986

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.