Evidence map›Paper›PMID 38718161›Full record

ArticleACS sensors2024

Synthesis and Evaluation of a Novel PET Radioligand for Imaging Glutaminyl Cyclase Activity as a Biomarker for Detecting Alzheimer's Disease.

William J Behof, Justin R Haynes, Clayton A Whitmore, Yiu-Yin Cheung, Mohammed N Tantawy, Todd E Peterson, Printha Wijesinghe, Joanne A Matsubara, Wellington Pham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS sensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William J BehofVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Justin R HaynesVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Clayton A WhitmoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Yiu-Yin CheungVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Mohammed N TantawyVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Todd E PetersonVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Printha WijesingheDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z3N9, Canada.
Joanne A MatsubaraDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z3N9, Canada.
Wellington PhamVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0002-8408-7611

Funding

Validation of Retinal Abeta as a Potential Biomarker of Alzheimer's DiseaseR01AG061138 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHAM, WELLINGTON · 2019 to 2023
$3.6M
PET System for Preclinical ResearchS10OD016245 · OD · VANDERBILT UNIVERSITY · PI PETERSON, TODD E · 2013 to 2013
$584k
NIA NIH HHS R01 AG061138NIH HHS S10 OD016245
6 · The paper itself

Abstract

Several new lines of research have demonstrated that a significant number of amyloid-β peptides found in Alzheimer's disease (AD) are truncated and undergo post-translational modification by glutaminyl cyclase (QC) at the N-terminal. Notably, QC's products of Abeta-pE3 and Abeta-pE11 have been active targets for investigational drug development. This work describes the design, synthesis, characterization, and in vivo validation of a novel PET radioligand, [

Indexed as

Alzheimer DiseaseAminoacyltransferasesPositron-Emission TomographyAmyloid beta-PeptidesAnimalsBiomarkersBrainFluorine RadioisotopesHumansLigandsMiceRadiopharmaceuticalsAminoacyltransferasesAmyloid beta-PeptidesBiomarkersFluorine Radioisotopesglutaminyl-peptide cyclotransferaseLigandsRadiopharmaceuticals[18F]PB0822Alzheimer’s diseaseglutaminyl cyclasePET imagingpyroglutamate Abeta

Identifiers

PMID38718161
PMCPMC11129349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.