ArticleScience advances2024
Cell deformability drives fluid-to-fluid phase transition in active cell monolayers.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Multicellular simulations with shape and volume constraints using optimal transport.Science advances · 2026Article
- Collective behavior of "flexicles".Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Rigidity transition of a highly compressible granular medium.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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2 authors.
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Abstract
Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for tissue homeostasis and stable developmental processes. However, large-scale simulations of deformable cells have been restricted to those of polygonal-shaped cells, limiting our understanding of populations of arbitrarily deformable cells, such as mesenchymal, amoeboid cells, and nonconfluent epithelial cells. Here, we present an efficient approach for simulating large populations of nonpolygonally deformable cells with considerably higher computational efficiency than existing methods. Using the method, we demonstrate that the densely packed active cell population interacting via excluded volume interactions exhibits a fluid-to-fluid transition. An experimentally measurable index of topological defects, defined using the number of neighboring cells, is also proposed to characterize this transition. This study provides a flexible approach to tissue-scale cell population and a broader perspective on the biological fluid phases.
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