ArticleScience advances2024
Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to
Abstract read
In one paragraph
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Nuclear mechanobiology: a brief history and five unresolved questions.Nucleus (Austin, Tex.) · 2026Article
- Nanomaterial-driven spatiotemporal autophagy modulation: The dual-edged sword in precision cancer therapy.Acta pharmaceutica Sinica. B · 2026Review
- Organelle network dysfunction in primary cardiomyopathy: An integrated perspective on pathogenesis and therapeutics.Journal of molecular and cellular cardiology plus · 2026Review
- Low-toxicity vitrification of small-diameter arterial grafts by achieving a Cryo-Stasis state.Materials today. Bio · 2026Article
- Review
- RNA-Based Therapies for Treating Monogenic Cardiomyopathies.The Canadian journal of cardiology · 2026Review
- Organelle homeostasis disruption: A driving force in the progression of cardiomyopathy (Review).Experimental and therapeutic medicine · 2026Review
- Comprehensive analysis of aberrant alternative splicing and RNA binding proteins regulators associated with myocardial ischemia reperfusion injury in mice.Scientific reports · 2026Article
- Perinuclear organelle trauma at the nexus of cardiomyopathy pathogenesis arising from loss of functionNucleus (Austin, Tex.) · 2025Review
- Microtubule forces drive nuclear damage in LMNA cardiomyopathy.Nature cardiovascular research · 2025Article
- Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage.Journal of advanced research · 2025Article
- Dexamethasone mitigates sulfur mustard-induced stem cell deficiency in vivo in rabbit limbal tissue by reducing inflammation and oxidative stress.Archives of toxicology · 2025Article
- Med25 Limits Master Regulators That Govern Adipogenesis.International journal of molecular sciences · 2023Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Kunal SikderCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0000-0002-4235-0936
Elizabeth PhillipsCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0009-0004-3965-4850
Zhijiu ZhongTranslational Research and Pathology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-9828-298X
Nadan WangCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0000-0002-1682-080X
Jasmine SaundersCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0009-0005-1098-8643
David MothyCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0000-0003-0583-4058
Andrew KossenkovBioinformatics Facility, The Wistar Institute Cancer Center, Philadelphia, PA, USA.ORCID 0000-0002-1536-0418
Timothy SchneiderMitocare, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0009-0005-1490-0717
Zuzana NichtovaMitocare, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0001-7358-3268
Gyorgy CsordasMitocare, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.ORCID 0000-0003-3156-1460
Kenneth B MarguliesCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8093-4465
Jason C ChoiCenter for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia PA, USA.ORCID 0009-0006-5175-4680
Funding
Integrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MCell type-specific function of LMNA during myocardial stress in the development of cardiomyopathyR01HL150019 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2020 to 2023
$1.6MDusp4 in the pathogenesis of LMNA cardiomyopathyR00HL118163 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI CHOI, JASON CHEOL · 2016 to 2018
$737kVevo 2100 ultrasound scannerS10OD010408 · OD · THOMAS JEFFERSON UNIVERSITY · PI FORSBERG, FLEMMING · 2012 to 2012
$525kNHLBI NIH HHS R00 HL118163NHLBI NIH HHS R01 HL150019NIH HHS S10 OD010408
Abstract
Mutations in the
Indexed as
CardiomyopathiesLamin Type AMyocytes, CardiacNuclear EnvelopeAnimalsAutophagyDisease Models, AnimalEndoplasmic Reticulum StressGolgi ApparatusMiceMice, KnockoutStress, PhysiologicalLamin Type ALmna protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.