Evidence map›Paper›PMID 38717950›Full record

ArticleHuman gene therapy2024

CRISPR-Cas Genome Editing in

Kumi Mesaki, Haruchika Yamamoto, Stephen Juvet, Jonathan Yeung, Zehong Guan, Akhi Akhter, Yan Yao, Cameron Dickie, Henna Mangat, Aizhou Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kumi MesakiLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.ORCID 0000-0003-1007-9587
Haruchika YamamotoLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Stephen JuvetLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Jonathan YeungLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Zehong GuanLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Akhi AkhterLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Yan YaoLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Cameron DickieLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Henna MangatLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Aizhou WangLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Gavin W WilsonLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Andrea MariscalLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Jim HuDepartment of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Alan R DavidsonDepartment of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Benjamin P KleinstiverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Marcelo CypelLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Mingyao LiuLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Shaf KeshavjeeLatner Thoracic Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

Funding

Scalable Development of Custom Genome Editing TechnologiesDP2CA281401 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2022 to 2025
$2.5M
NCI NIH HHS DP2 CA281401
6 · The paper itself

Abstract

The ongoing advancements in CRISPR-Cas technologies can significantly accelerate the preclinical development of both

Indexed as

CRISPR-Cas SystemsGene EditingLungAnimalsGenetic VectorsHumansInterleukin-10Interleukin-10CRISPRex vivo perfusiongenome editingIL-10precision-cut tissue slices

Identifiers

PMID38717950
PMCPMC11386987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.