ArticleBJS open2024
Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy: population-based cohort study.
Article in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Nationwide implementation of minimally invasive liver surgery: population-based analysis.BJS open · 2025Article
- Indocyanine green-assisted liver resection for colorectal liver metastases and factors associated with resection margin: a single-center retrospective study.World journal of surgical oncology · 2025Article
- Prognostic effect of surgical margin in patients undergoing hepatectomy for colorectal liver metastasis.Hepatobiliary surgery and nutrition · 2025Article
- Can We Achieve More with Less? Parenchymal Sparing Surgery Versus Major Liver Resection for Colorectal Liver Metastases: An Observational Single-Center Study with Propensity Score Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- The best of hepato-pancreato-biliary (HPB) surgery in BJS Open: advancing frontiers towards 2025.BJS open · 2024Article
- Curative-intent ablation margins (A0) for colorectal liver metastasis: more burning questions.The British journal of surgery · 2024Article
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9 authors.
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Abstract
backgroundResection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and ≥1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery.
methodsUsing data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model.
resultsA total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin <1 mm. The overall survival in patients with a margin of 0 mm or 0.1-0.9 mm was 42 (95% c.i. 31 to 53) and 48 (95% c.i. 35 to 62) months respectively, compared with 75 (95% c.i. 65 to 85) for patients with ≥1 mm margin, P < 0.001. Margins of 0 mm or 0.1-0.9 mm were associated with poor overall survival in the multivariable analysis, HR 1.413 (95% c.i. 1.030 to 1.939), P = 0.032, and 1.399 (95% c.i. 1.025 to 1.910), P = 0.034, respectively.
conclusionsDespite modern chemotherapy the resection margin is still an important factor for the survival of patients resected for colorectal liver metastasis, and a margin of ≥1 mm is needed to achieve the best possible outcome.
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