Evidence map›Paper›PMID 38717727›Full record

ArticleInternal and emergency medicine2024

Ulcerative colitis and nephrotic syndrome: a two-sample Mendelian randomization study.

Jinfeng Zhan, Yujie Rao, Jiahao Liu, Haizhou Miao, Zhongbin Xia

Abstract read
PubMed Publisher
In one paragraph

Article in Internal and emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinfeng Zhan *Health Management Medicine Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yujie Rao *Health Management Medicine Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiahao LiuThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Haizhou MiaoThe Fourth Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhongbin XiaHealth Management Medicine Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. 408979872@qq.com.ORCID 0000-0002-0251-2152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the potential causal relationship between ulcerative colitis and nephrotic syndrome. We obtained the whole-genome association study data of ulcerative colitis in the European population from the GWAS database. Relevant single nucleotide polymorphisms (SNPs) were selected for analysis. We employed the inverse variance-weighted meta-analysis of multiplicative random effects models to obtain SNP-specific Wald ratio estimates, which assume horizontal pleiotropy. In addition, we performed sensitivity analyses using MR-Egger, weighted median, and IVW. Our findings suggest a strong association between ulcerative colitis and nephrotic syndrome (P < 0.05). After conducting sensitivity analyses, we found no evidence of horizontal pleiotropy or heterogeneity (P > 0.05). This study provides evidence for an association between ulcerative colitis and nephrotic syndrome, which may help us better understand the conditions of ulcerative colitis and nephropathy.

Indexed as

Colitis, UlcerativeMendelian Randomization AnalysisNephrotic SyndromePolymorphism, Single NucleotideGenome-Wide Association StudyHumansMendelian randomization studyNephrotic syndromeUlcerative colitis

Identifiers

PMID38717727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.