Evidence map›Paper›PMID 38717685›Full record

ReviewMolecular and cellular biochemistry2025

The role of the ER stress sensor IRE1 in cardiovascular diseases.

Lu Zhou, Xizi Zhu, Shaoqing Lei, Yafeng Wang, Zhongyuan Xia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lu Zhou *Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Xizi Zhu *Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Shaoqing LeiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.
Yafeng WangDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. wangyafengaaa@163.com.
Zhongyuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China. xiazhongyuan2005@aliyun.com.

Funding

Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education 2023MZFS006
6 · The paper itself

Abstract

Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause of mortality worldwide. Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor endoplasmic reticulum (ER) transmembrane protein that senses ER stress. It manages ER stress induced by the accumulation of unfolded/misfolded proteins via the unfolded protein response (UPR). However, if the stress still persists, the UPR pathways are activated and induce cell death. Emerging evidence shows that, beyond the UPR, IRE1 participates in the progression of cardiovascular diseases by regulating inflammation levels, immunity, and lipid metabolism. Here, we summarize the recent findings and discuss the potential therapeutic effects of IRE1 in the treatment of cardiovascular diseases.

Indexed as

Cardiovascular DiseasesEndoplasmic Reticulum StressEndoribonucleasesProtein Serine-Threonine KinasesUnfolded Protein ResponseAnimalsHumansEndoribonucleasesERN1 protein, humanProtein Serine-Threonine KinasesCardiovascular diseasesEndoplasmic reticulum stressInositol-requiring enzyme 1Unfolded protein responseXBP1

Identifiers

PMID38717685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.