Evidence map›Paper›PMID 38717612›Full record

ArticleJournal of neurology2024

History of traumatic brain injury is associated with increased grey-matter loss in patients with mild cognitive impairment.

Marc A Khoury, Nathan W Churchill, Alex Di Battista, Simon J Graham, Sean Symons, Angela K Troyer, Angela Roberts, Sanjeev Kumar, Brian Tan, Stephen R Arnott and 16 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Marc A KhouryKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. marc.khoury@mail.utoronto.ca.
Nathan W ChurchillKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Alex Di BattistaDefence Research and Development Canada, Toronto Research Centre, Toronto, ON, Canada.
Simon J GrahamPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, Canada.
Sean SymonsDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Angela K TroyerNeuropsychology and Cognitive Health Program, Baycrest Hospital, Department of Psychology, University of Toronto, Toronto, ON, Canada.
Angela RobertsSchool of Communication Sciences and Disorders, Western University, London, ON, Canada.
Sanjeev KumarCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Brian TanRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Stephen R ArnottRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Joel RamirezSunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Maria C TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Michael BorrieSchulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Bruce PollockCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Tarek K RajjiCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Stephen H Pasternak. Joseph's Healthcare Centre, London, ON, Canada.
Andrew FrankBruyère Research Institute, Ottawa, ON, Canada.
David F Tang-WaiDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Christopher J M ScottSunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Seyyed Mohammad Hassan HaddadUniversity of Western, London, ON, Canada.
Nuwan NanayakkaraUniversity of Western, London, ON, Canada.
Joseph B OrangeSchool of Communication Sciences and Disorders, Western University, London, ON, Canada.
Alicia PeltschQueen's University, Kingston, ON, Canada.
Corinne E FischerKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
David G MunozKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Tom A SchweizerKeenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate whether a history of traumatic brain injury (TBI) is associated with greater long-term grey-matter loss in patients with mild cognitive impairment (MCI).

methods85 patients with MCI were identified, including 26 with a previous history of traumatic brain injury (MCI[TBI-]) and 59 without (MCI[TBI+]). Cortical thickness was evaluated by segmenting T1-weighted MRI scans acquired longitudinally over a 2-year period. Bayesian multilevel modelling was used to evaluate group differences in baseline cortical thickness and longitudinal change, as well as group differences in neuropsychological measures of executive function.

resultsAt baseline, the MCI[TBI+] group had less grey matter within right entorhinal, left medial orbitofrontal and inferior temporal cortex areas bilaterally. Longitudinally, the MCI[TBI+] group also exhibited greater longitudinal declines in left rostral middle frontal, the left caudal middle frontal and left lateral orbitofrontal areas sover the span of 2 years (median = 1-2%, 90%HDI [-0.01%: -0.001%], probability of direction (PD) = 90-99%). The MCI[TBI+] group also displayed greater longitudinal declines in Trail-Making-Test (TMT)-derived ratio (median: 0.737%, 90%HDI: [0.229%: 1.31%], PD = 98.8%) and differences scores (median: 20.6%, 90%HDI: [-5.17%: 43.2%], PD = 91.7%).

conclusionsOur findings support the notion that patients with MCI and a history of TBI are at risk of accelerated neurodegeneration, displaying greatest evidence for cortical atrophy within the left middle frontal and lateral orbitofrontal frontal cortex. Importantly, these results suggest that long-term TBI-mediated atrophy is more pronounced in areas vulnerable to TBI-related mechanical injury, highlighting their potential relevance for diagnostic forms of intervention in TBI.

Indexed as

Brain Injuries, TraumaticCognitive DysfunctionGray MatterMagnetic Resonance ImagingAgedBayes TheoremCerebral CortexFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsBayesian statisticsMagnetic resonance imaging (MRI)Mild-cognitive-impairment (MCI)NeurodegenerationTraumatic brain injury (TBI)

Identifiers

PMID38717612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.