Evidence map›Paper›PMID 38717591›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Efficiency of succinylated gelatin and amino acid infusions for kidney uptake reduction of radiolabeled αvβ6-integrin targeting peptides: considerations on clinical safety profiles.

Stefan Stangl, Nghia Trong Nguyen, Julia Brosch-Lenz, Jakub Šimeček, Wolfgang A Weber, Susanne Kossatz, Johannes Notni

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. First αvβ6-integrin targeted radioligand therapy of breast cancer using Lu-177-Therahexin.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Radioligand therapy of pancreatic ductal adenocarcinoma using an αvβ6-integrin targetingEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Synthesis and preclinical development of a novelEJNMMI radiopharmacy and chemistry · 2026
    Article
  6. Review
  7. PET/CT imaging of esophageal cancer targeting tumor cell specific αvβ6-integrin expression.European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefan StanglDepartment of Nuclear Medicine, University Hospital Klinikum Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Nghia Trong NguyenDepartment of Nuclear Medicine, University Hospital Klinikum Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Julia Brosch-LenzDepartment of Nuclear Medicine, University Hospital Klinikum Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Jakub ŠimečekTRIMT GmbH, Radeberg, Germany.
Wolfgang A WeberDepartment of Nuclear Medicine, University Hospital Klinikum Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Susanne Kossatz *Department of Nuclear Medicine, University Hospital Klinikum Rechts Der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany. s.kossatz@tum.de.
Johannes Notni *TRIMT GmbH, Radeberg, Germany. jn@trimt.de.ORCID 0000-0002-3964-3391

Funding

Sächsische Aufbaubank #100685203Sächsische Aufbaubank project INTRA
6 · The paper itself

Abstract

purpose

methodsEx-vivo biodistribution of

resultsKidney uptake of

conclusionsThe kidney uptake of both investigated radiopharmaceuticals was more efficiently reduced by gelofusine (61-85%) than Arg/Lys (25-41%). Gelofusine appears particularly suitable for reducing renal uptake of αvβ6-integrin targeted

Indexed as

Amino AcidsGelatinIntegrinsKidneySuccinatesAnimalsAntigens, NeoplasmBiological TransportCell Line, TumorClinical Trials, Phase I as TopicGallium RadioisotopesLutetiumMiceMice, Inbred C57BLPeptidesPositron-Emission TomographyAmino AcidsAntigens, NeoplasmGallium RadioisotopesGelatinintegrin alphavbeta6IntegrinsLutetiumLutetium-177PeptidesRadioisotopesRadiopharmaceuticalsSuccinatessuccinylated gelatinArginineKidney protectionLysinePeptide receptor radionuclide therapySuccinylated gelatin

Identifiers

PMID38717591
PMCPMC11369040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.