Evidence map›Paper›PMID 38717568›Full record

ArticleBulletin of experimental biology and medicine2024

Emotional Stress Induces Adaptive Response in Rat Lymphocytes to Subsequent Ionizing Radiation Exposure.

P E Umryukhin, E N Mikheeva, U M Mishina, E V Proskurnina, E M Malinovskaya, A V Martynov, E S Ershova, N N Veiko, S V Kostyuk

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

P E UmryukhinResearch Centre for Medical Genetics, Moscow, Russia. pavelum@mail.ru.
E N MikheevaI. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
U M MishinaI. M. Se-chenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
E V ProskurninaResearch Centre for Medical Genetics, Moscow, Russia.
E M MalinovskayaResearch Centre for Medical Genetics, Moscow, Russia.
A V MartynovResearch Centre for Medical Genetics, Moscow, Russia.
E S ErshovaResearch Centre for Medical Genetics, Moscow, Russia.
N N VeikoResearch Centre for Medical Genetics, Moscow, Russia.
S V KostyukResearch Centre for Medical Genetics, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the molecular mechanisms of cross-adaptation to ionizing radiation (1 Gy) of lymphocytes isolated from rats subjected to emotional stress. The effects of chronic (CES; various types of stress exposure) and acute (AES; forced swimming) emotional stress in rats on indicators of oxidative stress, cell death, and levels of NRF2 and NOX4 proteins involved in the development of the adaptive response were analyzed in isolated lymphocytes. It was found that stress induced an adaptive response in rat lymphocytes and triggered processes similar to the adaptive response induced by low doses of ionizing radiation: an increase in the level of oxidized DNA and cell death, as well as an increase in the content of NOX4 and NRF2 proteins. In animals subjected to emotional stress, suppressed DNA oxidation in response to irradiation, reduced levels of protective factor NRF2, as well as lymphocyte death were observed.

Indexed as

LymphocytesNF-E2-Related Factor 2Oxidative StressRadiation, IonizingStress, PsychologicalAdaptation, PhysiologicalAnimalsDNA DamageMaleNADPH Oxidase 4RatsRats, WistarNADPH Oxidase 4Nfe2l2 protein, ratNF-E2-Related Factor 2adaptive responseemotional stresslymphocytesradiation

Identifiers

PMID38717568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.