Evidence map›Paper›PMID 38717567›Full record

ArticleBulletin of experimental biology and medicine2024

Blood Level of Nitric Oxide Metabolites and Expression of Genes Regulating NO Synthesis in Early Forms of Non-Alcoholic Fatty Liver Disease.

I V Kurbatova, L V Topchieva, O P Dudanova, A A Shipovskaya, N P Kantserova, I E Malysheva

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I V KurbatovaMedical Biological Research Center, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia. irina7m@yandex.ru.
L V TopchievaMedical Biological Research Center, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia.
O P DudanovaPetrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia.
A A ShipovskayaPetrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia.
N P KantserovaMedical Biological Research Center, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia.
I E MalyshevaMedical Biological Research Center, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The levels of NO metabolites in the plasma and mRNA of the NOS3, ATG9B, and NOS2 genes in peripheral blood leukocytes of healthy people and patients with early forms of non-alcoholic fatty liver disease (steatosis and weak activity non-alcoholic steatohepatitis) were studied. In patients with steatohepatitis, the concentration of NO metabolites in the blood and the level of mRNA of the NOS2 gene were higher than in patients with steatosis and healthy people. These differences can be of diagnostic value for distinguishing between steatosis and weak activity steatohepatitis in non-alcoholic fatty liver disease. A correlation between the levels of NO metabolites and the expression of the NOS2 gene in weak activity steatohepatitis was established, which indicates activation of NO synthesis in non-alcoholic steatohepatitis due to the expression of the inducible NO synthase gene. The level of the NOS2 gene mRNA in peripheral blood leukocytes of patients with weak activity steatohepatitis correlated with the level of TNFα and IL-6 cytokines. An increase in the level of NO in the blood in weak activity steatohepatitis correlated with the level of MDA, an indicator of oxidative stress.

Indexed as

Interleukin-6Nitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINon-alcoholic Fatty Liver DiseaseTumor Necrosis Factor-alphaAdultCase-Control StudiesFemaleHumansMaleMalondialdehydeMiddle AgedOxidative StressRNA, MessengerIL6 protein, humanInterleukin-6MalondialdehydeNitric OxideNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINOS2 protein, humanNOS3 protein, humanRNA, MessengerTumor Necrosis Factor-alphaATG9Bnitric oxidenitric synthasenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitis

Identifiers

PMID38717567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.