Evidence map›Paper›PMID 38717454›Full record

ArticleThe Journal of cell biology2024

A collective strategy to promote the dissemination of single cancer cells.

Peter Friedl, Mirjam Zegers

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Peter FriedlDepartment of Medical BioSciences, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0002-0119-4041
Mirjam ZegersDepartment of Medical BioSciences, Radboud University Medical Centre, Nijmegen, Netherlands.ORCID 0000-0002-1190-4094

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transition from collective to single-cell invasion in metastatic tumors has been regarded as the consequence of oncogenic drivers in concert with extracellular triggers received from the tumor microenvironment. In this issue, Yoon and colleagues (https://doi.org/10.1083/jcb.202308080) have identified an epigenetic program by which collective niches release laminin-332 and thereby cause the detachment and invasion of fully individualized tumor cells.

Indexed as

NeoplasmsTumor MicroenvironmentAnimalsEpigenesis, GeneticHumansNeoplasm Invasiveness

Identifiers

PMID38717454
PMCPMC11080643

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.