Evidence map›Paper›PMID 38717443›Full record

ArticleAmerican journal of respiratory and critical care medicine2024

Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.

Avraham Unterman, Amy Y Zhao, Nir Neumark, Jonas C Schupp, Farida Ahangari, Carlos Cosme, Prapti Sharma, Jasper Flint, Yan Stein, Changwan Ryu and 7 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  3. Trial
  4. Article
  5. Acute exacerbation in fibrotic interstitial lung disease: an international working group report.American journal of respiratory and critical care medicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The transcriptome of CD14The European respiratory journal · 2026
    Article
  13. Article
  14. Article
  15. Immunological mechanisms and therapeutic approaches in pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Avraham UntermanSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0003-0965-3326
Amy Y ZhaoSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0003-0481-2885
Nir NeumarkSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-5560-6136
Jonas C SchuppSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-7714-8076
Farida AhangariSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-4144-9395
Carlos CosmeSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-2684-2615
Prapti SharmaSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0009-0009-8544-341X
Jasper FlintSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.
Yan SteinPulmonary Fibrosis Center, Institute of Pulmonary Medicine and.ORCID 0000-0003-0335-5897
Changwan RyuSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0001-6211-4327
Genta IshikawaSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-8882-8288
Tomokazu S SumidaDepartment of Neurology, School of Medicine, Yale University, New Haven, Connecticut.ORCID 0000-0002-9806-2642
Jose L GomezSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-6521-6318
Jose D Herazo-MayaDivision of Pulmonary, Critical Care and Sleep Medicine, University of South Florida, Morsani College of Medicine, Tampa, Florida.ORCID 0000-0002-8129-6346
Charles S Dela CruzSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-5258-1797
Erica L HerzogSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0002-7508-8575
Naftali KaminskiSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, and.ORCID 0000-0001-5917-4601

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Noradrenergic mechanisms of IPFR01HL163984 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog · 2022 to 2026
$3.7M
Systems Biology of a MicroRNA Network in Neutrophilic AsthmaR01HL153604 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2020 to 2024
$3.4M
Epithelial Protective Effects of Thyroid Hormone Signaling in FibrosisR01HL141852 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$3.4M
Normal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8M
Macrophage driven, profibrotic adrenergic nerve remodeling in SSc-ILDR01HL152677 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2020 to 2023
$2.4M
Mitochondrial DNA and TLR9 in Pulmonary FibrosisK08HL151970 · NHLBI · YALE UNIVERSITY · PI RYU, CHANGWAN · 2020 to 2024
$840k
Integrating single-cell based transcriptomic signatures for identifying therapeutic targets of COPDR21HL161723 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2022 to 2023
$251k
Identifying Disease-Specific Immune Cell Shifts in Chronic Fibrotic Interstitial Lung Diseases with Single-Cell RNA SequencingF30HL162459 · NHLBI · YALE UNIVERSITY · PI ZHAO, AMY YUE-TING · 2022 to 2025
$173k
Regulation of Neutrophilic Airway Inflammation by miR-223-3pR03HL154275 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2020 to 2021
$168k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS F30 HL162459NHLBI NIH HHS K08 HL151970NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01 HL141852NHLBI NIH HHS R01 HL152677NHLBI NIH HHS R01 HL153604NHLBI NIH HHS R01 HL163984NHLBI NIH HHS R03 HL154275NHLBI NIH HHS R21 HL161723NHLBI NIH HHS U01 HL145567NIGMS NIH HHS T32 GM136651Pulmonary Fibrosis FoundationThree Lakes Partners
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisLeukocytes, MononuclearSingle-Cell AnalysisT-Lymphocytes, RegulatoryAgedCase-Control StudiesDisease ProgressionFemaleFlow CytometryHumansMaleMiddle Agedimmune systemIPFmonocytesregulatory T cellssingle-cell RNA sequencing

Identifiers

PMID38717443
PMCPMC11351796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.