ArticleAnalytical chemistry2024
Interfacing High-Throughput Electrosynthesis and Mass Spectrometric Analysis of Azines.
Article in Analytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- An Automated Electrochemistry Platform for Accelerating the Characterization of Enzymatic Electrochemistry.ACS electrochemistry · 2026Article
- Materials Acceleration Platform for Electrochemistry: a Platform for Autonomous Electrochemistry.Npj Materials degradation · 2026Article
- Seeing the unseen: spatio-temporal visualization of reactive carbocation intermediates in electrolytic cells.Chemical science · 2025Article
- Scanning Electrochemical Cell Microscopy for Sub-Micrometer Mass Spectrometric Studies of Electrochemical Reactions.ACS electrochemistry · 2025Article
- Electrochemical correlative microscopy: Discovering insights into structure-reactivity relationships for electrochemical energy conversion and storage.Current opinion in electrochemistry · 2025Article
- Identifying Reactive Trends in Glycerol Electro-Oxidation Using an Automated Screening Approach: 28 Ways to Electrodeposit an Au Electrocatalyst.ACS catalysis · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combinatorial electrochemistry has great promise for accelerated reaction screening, organic synthesis, and catalysis. Recently, we described a new high-throughput electrochemistry platform, colloquially named "Legion". Legion fits the footprint of a 96-well microtiter plate with simultaneous individual control over all 96 electrochemical cells. Here, we demonstrate the versatility of Legion when coupled with high-throughput mass spectrometry (MS) for electrosynthetic product screening and quantitation. Electrosynthesis of benzophenone azine was selected as a model reaction and was arrayed and optimized using a combination of Legion and nanoelectrospray ionization MS. The combination of high-throughput synthesis with Legion and analysis via MS proves a compelling strategy for accelerating reaction discovery and optimization in electro-organic synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.