Evidence map›Paper›PMID 38717141›Full record

ArticlemBio2024

On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rebecca C S EdgarSchool of Medicine, Deakin University, Geelong, Australia.ORCID 0000-0002-5974-8625
Tess R MalcolmMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Ghizal SiddiquiDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Carlo GiannangeloDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Natalie A CounihanSchool of Medicine, Deakin University, Geelong, Australia.
Matthew ChallisDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Sandra DuffyDiscovery Biology, Centre for Cellular Phenomics, Griffith University, Nathan, Queensland, Australia.ORCID 0000-0002-2814-1193
Mrittika ChowdhurySchool of Medicine, Deakin University, Geelong, Australia.
Jutta MarfurtGlobal Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Madeline DansSchool of Medicine, Deakin University, Geelong, Australia.
Grennady WirjanataGlobal Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Rintis NoviyantiEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Kajal DawareMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Chathura D SuraweeraMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Ric N PriceGlobal Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.
Sergio WittlinSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Vicky M AverySchool of Environment and Science, Griffith Sciences, Griffith University, Nathan, Queensland, Australia.ORCID 0000-0003-4914-2299
Nyssa DrinkwaterMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.
Susan A CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.
Darren J CreekDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.ORCID 0000-0001-7497-7082
Tania F de Koning-WardSchool of Medicine, Deakin University, Geelong, Australia.ORCID 0000-0001-5810-8063
Peter J ScammellsMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.ORCID 0000-0003-2930-895X
Sheena McGowanMonash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.ORCID 0000-0001-6863-1106

Funding

DHAC | National Health and Medical Research Council (NHMRC) 1136300DHAC | National Health and Medical Research Council (NHMRC) 1150359DHAC | National Health and Medical Research Council (NHMRC) 1185354Therapeutic Innovation Australia (TIA)
6 · The paper itself

Abstract

To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound

Indexed as

AminopeptidasesAntimalarialsPlasmodium falciparumPlasmodium vivaxAnimalsDrug ResistanceFemaleHumansMalaria, FalciparumMiceProtozoan ProteinsAminopeptidasesAntimalarialsProtozoan Proteinsaminopeptidasedrug resistancemalariaPlasmodium falciparumPlasmodium vivax

Identifiers

PMID38717141
PMCPMC11237774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.