Evidence map›Paper›PMID 38717092›Full record

ArticleAntimicrobial agents and chemotherapy2024

Phage K exposure generates phage-neutralizing activity in a rabbit model-humoral receptiveness may impact efficacy of phage therapy.

Sebastian C Herren, Melissa J Karau, Christina A Koscianski, Trace A Christensen, Dane Granger, Nathanial G Bergan, Jay Mandrekar, David R Holmes, Robin Patel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Multidrug-resistantFrontiers in microbiology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sebastian C HerrenDepartment of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0009-0002-2570-4250
Melissa J KarauDepartment of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Christina A KoscianskiDepartment of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Trace A ChristensenDepartment of Biochemistry and Molecular Biology, Microscopy and Cell Analysis Core Facility, Mayo Clinic, Rochester, Minnesota, USA.
Dane GrangerDepartment of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.
Nathanial G BerganDepartment of Physiology and Biomedical Engineering, Biomedical Imaging Resource Core Facility, Mayo Clinic, Rochester, Minnesota, USA.
Jay MandrekarDepartment of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
David R HolmesDepartment of Physiology and Biomedical Engineering, Biomedical Imaging Resource Core Facility, Mayo Clinic, Rochester, Minnesota, USA.
Robin PatelDepartment of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6344-4141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage therapy has not been established in the clinical routine, in part due to uncertainties concerning efficacy and immunogenicity. Here, three rabbits were immunized against staphylococcal phage K to assess viral potency in the presence of immunized serum. Three rabbits received weekly intramuscular injections of ~10

Indexed as

Immunoglobulin GPhage TherapyAnimalsAntibodies, ViralEnzyme-Linked Immunosorbent AssayMicroscopy, Electron, TransmissionRabbitsStaphylococcal InfectionsStaphylococcus aureusStaphylococcus PhagesAntibodies, ViralImmunoglobulin Ghumoral receptivenessimmunogold labelingK-rateMRSAphage-antibodiesphage Kphage therapyStaphylococcus aureus

Identifiers

PMID38717092
PMCPMC11622735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.