Evidence map›Paper›PMID 38716980›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2024

Moderate physical exercise and ATP modulate the P2X7 receptor and improve cisplatin-induced gastric emptying delay in rats.

Y A Gomes, W L L Santos, C S Pinheiro, J S Severo, J C C Oliveira Júnior, A C A da Silva, B L B Dos Santos, C H L Rocha, A A Dos Santos, M T B da Silva

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In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Y A GomesPrograma de Pós-Graduação em Farmacologia, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0002-2622-717X
W L L SantosPrograma de Pós-Graduação em Alimentos e Nutrição, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0002-5682-2498
C S PinheiroPrograma de Pós-Graduação em Farmacologia, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0002-2858-5536
J S SeveroPrograma de Pós-Graduação em Alimentos e Nutrição, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0002-1771-7871
J C C Oliveira JúniorLaboratório de Exercício e Trato Gastrintestinal, Departamento de Educação Física, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0009-0007-8727-3114
A C A da SilvaPrograma de Pós-Graduação em Farmacologia, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0003-3194-1471
B L B Dos SantosLaboratório de Exercício e Trato Gastrintestinal, Departamento de Educação Física, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0003-3396-0123
C H L RochaOncoclínica, Teresina, PI, Brasil.ORCID http://orcid.org/0009-0004-6619-8723
A A Dos SantosDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0003-0912-3720
M T B da SilvaPrograma de Pós-Graduação em Farmacologia, Universidade Federal do Piauí, Teresina, PI, Brasil.ORCID http://orcid.org/0000-0002-6178-9880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing chemotherapy with cisplatin commonly present gastrointestinal effects such as constipation and gastric emptying (GE) delay. Both the purinergic system and physical exercise modulate the gastrointestinal (GI) tract. In the current study, we investigated the role of ATP, physical exercise, and P2X7 receptor blocking on GE delay induced by cisplatin in rats. Male rats were divided into the following groups: control (C), cisplatin (Cis), exercise (Ex), Brilliant Blue G (BBG), ATP, Cis+Ex, Cis+ATP, Cis+BBG, Cis+Ex+BBG, Cis+Ex+BBG+ATP, and Cis+ATP+BBG. GE delay was induced by treatment with 1 mg/kg cisplatin (1 time/week for 5 weeks, ip). The moderate physical exercise was swimming (1 h/day, 5 days/week for 5 weeks). At the end of the treatment or exercise and 30 min before the GE assessment, some groups received BBG (50 mg/kg, sc) or ATP (2 mg/kg, sc). Then, GE was assessed after a 10-min postprandial period. Chronic use of Cis decreased GE delay (P<0.05) compared to the control group. Both exercise and ATP prevented (P<0.05) GE delay compared to Cis. The pretreatment with BBG significantly inhibited (P<0.05) the effect of exercise and ATP. On the other hand, the association between exercise and ATP reversed (P<0.05) the effect of the BBG and prevented GE delay. Therefore, we suggest that both exercise and treatment with ATP activate P2X7 receptors and prevent GE delay induced by cisplatin in rats.

Indexed as

Adenosine TriphosphateAntineoplastic AgentsCisplatinGastric EmptyingPhysical Conditioning, AnimalRats, WistarReceptors, Purinergic P2X7AnimalsMalePurinergic P2X Receptor AntagonistsRatsAdenosine TriphosphateAntineoplastic AgentsCisplatinPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7

Identifiers

PMID38716980
PMCPMC11085034

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.