Evidence map›Paper›PMID 38716867›Full record

ReviewImmunological reviews2024

Microbial influences on severity and sex bias of systemic autoimmunity.

Jean Lee, Derek Reiman, Samara Singh, Anthony Chang, Laurence Morel, Alexander V Chervonsky

Abstract readReview
In one paragraph

Review in Immunological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Autoimmunity and the microbiome.Immunological reviews · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jean LeeCommittee on Cancer Biology, The University of Chicago, Chicago, Illinois, USA.
Derek ReimanToyota Technological Institute at Chicago, Chicago, Illinois, USA.
Samara SinghDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.
Anthony ChangDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.
Laurence MorelDepartment of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.ORCID 0000-0002-6622-1290
Alexander V ChervonskyDepartment of Pathology, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0001-7547-871X

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Host's and microbiota's contribution to sexual dimorphism of autoimmunityR01AI127411 · NIAID · UNIVERSITY OF CHICAGO · PI ALEXANDER V CHERVONSKY · 2017 to 2026
$5.4M
Gut dysbiosis and tryptophan metabolism in lupusR01AI143313 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Laurence Morel, Gregg Joshua Silverman · 2019 to 2026
$3.3M
Probing short and long term consequences of Small and Large Bowel Microbiota Transplants on Host Physiology: Implications for the development of future live biotherapeuticsR01DK138072 · NIDDK · UNIVERSITY OF CHICAGO · PI EUGENE B CHANG, Kristina Brooke Martinez-Guryn · 2024 to 2026
$2.1M
CSR NIH HHS AI127411CSR NIH HHS AI143313CSR NIH HHS P30 CA014599NCI NIH HHS P30 CA014599NIAID NIH HHS R01 AI127411NIAID NIH HHS R01 AI143313NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK138072
6 · The paper itself

Abstract

Commensal microbes have the capacity to affect development and severity of autoimmune diseases. Germ-free (GF) animals have proven to be a fine tool to obtain definitive answers to the queries about the microbial role in these diseases. Moreover, GF and gnotobiotic animals can be used to dissect the complex symptoms and determine which are regulated (enhanced or attenuated) by microbes. These include disease manifestations that are sex biased. Here, we review comparative analyses conducted between GF and Specific-Pathogen Free (SPF) mouse models of autoimmunity. We present data from the B6;NZM-Sle1

Indexed as

AutoimmunityDisease Models, AnimalLupus Erythematosus, SystemicAnimalsFemaleGerm-Free LifeHumansMaleMiceMicrobiotaSeverity of Illness IndexSex CharacteristicsSex FactorsSpecific Pathogen-Free OrganismsB6.NZMgerm‐freemicrobiotasex biasSLEsystemic autoimmunity

Identifiers

PMID38716867
PMCPMC11338725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.