Evidence map›Paper›PMID 38716382›Full record

ArticleResuscitation plus2024

Impact of arginine-vasopressin on regional perfusions in a porcine model of post-resuscitation syndrome.

Antoine Bois, Yara Abi Zeid Daou, Naoto Watanabe, Ali Jendoubi, Fanny Lidouren, Estelle Faucher, Nadir Mouri, Bijan Ghaleh, Guillaume Geri, Renaud Tissier and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antoine BoisINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Yara Abi Zeid DaouINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Naoto WatanabeINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Ali JendoubiINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Fanny LidourenINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Estelle FaucherINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Nadir MouriAssistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Département de Biochimie-pharmacologie, Créteil, France.
Bijan GhalehINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Guillaume GeriIntensive Care Unit, Ambroise Paré Private Hospital, Neuilly-sur-Seine, France.
Renaud TissierINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.
Matthias KohlhauerINSERM, U955, IMRB, Team 3, AfterROSC Network, Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Post-cardiac arrest (CA) shock is associated with multiple organ failure, including acute kidney injury, and is the leading cause of early death among patient successfully resuscitated from CA. Arginine-vasopressin (AVP) may be an interesting therapeutic alternative or complement to noradrenaline (NAD) to both control shock and preserve regional, especially renal, organ perfusions. Methods: 18 swine (24-39 kg) were submitted to 14 min of ventricular fibrillation and cardio-pulmonary resuscitation. After return of spontaneous circulation (ROSC), animals randomly received either AVP, NAD or AVP-NAD combination for maintaining a targeted mean arterial pressure of 70 ± 5 mmHg for 6 h. Haemodynamic and biological parameters, including kidney function biomarkers and diuresis, were monitored throughout the follow-up. Results: Targeted mean arterial pressure was successfully obtained in the NAD ( Conclusion: Combination of AVP and NAD improved renal perfusion and diuresis but reduced carotid blood flow as compared to NAD alone in a porcine model of post-resuscitation syndrome. AVP alone failed to manage shock and led to mortality.

Indexed as

Blood flowCardiac arrestResuscitationShockVasopressinVasopressor

Identifiers

PMID38716382
PMCPMC11074971

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.