Evidence map›Paper›PMID 38716363›Full record

ArticleAnemia2024

Detection of Asymptomatic Sickle Cell Hemoglobin Carriers and Fetal Hemoglobin Regulating Genetic Variants in African Descendants from Oaxaca, Mexico.

María De Los Ángeles Romero-Tlalolini, Sergio Roberto Aguilar-Ruiz, Rafael Baltiérrez-Hoyos, Jaime Vargas-Arzola, Luis Alberto Hernández-Osorio, Verónica Rocío Vásquez-Garzón, Héctor Ulises Bernardino-Hernández, Honorio Torres-Aguilar

Abstract read
In one paragraph

Article in Anemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pleiotropic Effects of Polymorphisms in theInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

María De Los Ángeles Romero-TlaloliniCONACYT-Medicine and Surgery Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0001-9867-8765
Sergio Roberto Aguilar-RuizCONACYT-Medicine and Surgery Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0002-2412-0360
Rafael Baltiérrez-HoyosCONACYT-Medicine and Surgery Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0003-3416-6917
Jaime Vargas-ArzolaChemical Sciences Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0003-3488-8821
Luis Alberto Hernández-OsorioChemical Sciences Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0001-8411-3376
Verónica Rocío Vásquez-GarzónCONACYT-Medicine and Surgery Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0002-4861-8235
Héctor Ulises Bernardino-HernándezChemical Sciences Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0003-0145-2175
Honorio Torres-AguilarChemical Sciences Faculty, Universidad Autónoma "Benito Juárez" de Oaxaca, Oaxaca, Mexico.ORCID https://orcid.org/0000-0003-2853-4891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell anemia has been classified as a noninfectious neglected tropical disease and, although not exclusively, affects African descendants more frequently. This study aimed to detect asymptomatic sickle cell hemoglobin carriers (HbAS) in marginalized and vulnerable populations during a public health screening in African descendants from Oaxaca, Mexico, and to validate an amplification refractory mutation system (ARMS)-PCR methodology to detect fetal-hemoglobin (HbF)-regulating genetic variants in BCL11A toward affordable routine association of single nucleotide variants (SNVs) with HbF concentrations. To this aim, hemoglobin variants were detected by acidic citrate agar and alkaline cellulose acetate electrophoreses. SNVs in the hemoglobin subunit beta gene (HBB) were identified by the

Identifiers

PMID38716363
PMCPMC11074717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.