Evidence map›Paper›PMID 38716347›Full record

ArticleFree neuropathology2024

Malignant glioma in L-2-Hydroxyglutaric Aciduria: thorough molecular characterization of a case and literature review.

Fleur Cordier, Pieter Wesseling, Bastiaan B J Tops, Lennart Kester, Pim J French, Martin van den Bent, Felix Hinz, Eleonora Aronica, K Mariam Slot, Floor Abbink and 2 more

Abstract read
In one paragraph

Article in Free neuropathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Subtle clinical and radiological findings as potential indicators of CNS tumors in L-2-hydroxyglutaric aciduria: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. L-2-Hydroxyglutaric Aciduria Complicated by Cerebral Neoplasm.Movement disorders clinical practice · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fleur CordierPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Pieter WesselingPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Bastiaan B J TopsPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Lennart KesterPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Pim J FrenchDepartment of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Martin van den BentDepartment of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Felix HinzDepartment of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Eleonora AronicaDepartment of Pathology, Amsterdam University Medical Centers (UMC), University of Amsterdam (EA) and Vrije Universiteit Amsterdam (PW), Amsterdam Neuroscience, The Netherlands.
K Mariam SlotDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Floor AbbinkDepartment of Pediatric Oncology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Marjo S van der KnaapDepartment of Pediatric Neurology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Mariëtte E G KranendonkPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-2-hydroxyglutaric aciduria (L-2-HGA) is a rare neurometabolic disorder characterized by accumulation of L2-hydroxyglutarate (L-2-HG) due to mutations in the

Indexed as

CNS tumorDNA-methylation-classificationL-2-hydroxyglutaric aciduriaPaediatric-type diffuse high-grade gliomaSequencing

Identifiers

PMID38716347
PMCPMC11075094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.