Evidence map›Paper›PMID 38716151›Full record

ArticleAnalytical science advances2021

Determining site occupancy of acetaminophen covalent binding to target proteins in vitro.

Timon Geib, Cristina Lento, Vanessa Marensi, Madhuranayaki Thulasingam, Jesper Z Haeggström, Magnus Olsson, Derek J Wilson, Elaine M Leslie, Lekha Sleno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Cortical Mechanisms Contributing to Ketamine-Induced Dissociation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Timon GeibChemistry Department Université du Québec à Montréal Montréal Canada.
Cristina LentoDepartment of Chemistry/The Centre for Research in Mass Spectrometry York University Toronto Canada.
Vanessa MarensiDepartment of Physiology University of Alberta Edmonton Canada.
Madhuranayaki ThulasingamDivision of Physiological Chemistry II Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden.
Jesper Z HaeggströmDivision of Physiological Chemistry II Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden.
Magnus OlssonUnit of Biochemical Toxicology Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden.
Derek J WilsonDepartment of Chemistry/The Centre for Research in Mass Spectrometry York University Toronto Canada.
Elaine M LeslieDepartment of Physiology University of Alberta Edmonton Canada.
Lekha SlenoChemistry Department Université du Québec à Montréal Montréal Canada.ORCID https://orcid.org/0000-0001-7923-8019

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetaminophen (APAP)-related toxicity is caused by the formation of

Indexed as

acetaminophenglutathione S‐transferasemultiple reaction monitoringN‐acetyl p‐benzoquinone imineprotein covalent bindingprotein modificationsreactive metabolitesite occupancy

Identifiers

PMID38716151
PMCPMC10989598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.