Evidence map›Paper›PMID 38715961›Full record

ArticleAnalytical science advances2021

Isolation, separation, identification, and quantification of bioactive methylated flavone regioisomers by UHPLC-MS/MS.

Hafiza Noreen, Edward N Smith, Muhammad Farman, Tim D W Claridge, James S O McCullagh

Abstract read
In one paragraph

Article in Analytical science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hafiza NoreenDepartment of Chemistry Quaid-i-Azam University Islamabad Pakistan.
Edward N SmithChemistry Research Laboratory Department of Chemistry University of Oxford Mansfield Road Oxford UK.
Muhammad FarmanDepartment of Chemistry Quaid-i-Azam University Islamabad Pakistan.
Tim D W ClaridgeChemistry Research Laboratory Department of Chemistry University of Oxford Mansfield Road Oxford UK.
James S O McCullaghChemistry Research Laboratory Department of Chemistry University of Oxford Mansfield Road Oxford UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylated flavones, commonly found in many plants of the Brassicaceae family, have potent antioxidant and anticancer activity with diverse therapeutic potential. However, the specific regioisomers of methylated flavones can have significantly different biochemical and potentially therapeutic properties as shown by various bioassays but analytically differentiating these compounds has been technically challenging and rarely reported. In this study, we demonstrate differentiation and identification of selected bioactive methylated flavone regioisomers, namely 5,7,3'-trihydroxy-4'-methoxyflavone, and 5,7,4'-trihydroxy-3'-methoxyflavone extracted from

Indexed as

Coronopus didymusflavonoidsmethylated flavoneproduct ionsregioisomers

Identifiers

PMID38715961
PMCPMC10989521

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.