ReviewFrontiers in neurology2024
Multimodal imaging of optic nerve head abnormalities in high myopia.
Review in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Optic disc morphology and myopia severity in eyes with peripapillary hyperreflective ovoid mass-like structures.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Optic Nerve Head Parameters and Their Associations With Axial Length and Refractive Status in Cynomolgus Macaques.Investigative ophthalmology & visual science · 2026Article
- Automated Optic Disc Tilt Classification in Fundus Photographs Using Segmentation and the Elliptical Ratio: External Clinical Validation Study.JMIR formative research · 2026Article
- Evaluation of retinochoroidal changes after implantable collamer lens implantation: insights from UWF-SS-OCTA and AI-based 3D modeling.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Stereophotographic Assessment of Intraocular Pressure Reduction in Myopic Eyes with Glaucoma-Compatible Optic Neuropathy.Ophthalmology and therapy · 2026Article
- Differences of the lamina cribrosa between primary open angle glaucoma and non-pathologic high myopia.International journal of ophthalmology · 2026Review
- 3D Structural Phenotype of the Optic Nerve Head in Glaucoma and Myopia-A Key to Improving Glaucoma Diagnosis in Myopic Populations.American journal of ophthalmology · 2026Article
- Clinical features of high myopia with optic nerve head prelaminar schisis: Wuhan high myopia study.Eye (London, England) · 2025Article
- Interpupillary Distance and Peripapillary Myopic Changes: A Pilot Study in a Glaucomatous Cohort.Journal of clinical medicine · 2025Article
- Comparative analysis of the optic nerve microvasculature between different optic disc phenotypes of normal-tension glaucoma patients.BMC ophthalmology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly myopic optic nerve head (ONH) abnormalities encompass a series of complications resulting from the stretching of papillary and peripapillary structures during significant axial elongation. The morphological changes in the ONH typically initiate with disk tilting or rotation, progressing to PHOMS and PPA. Tissue defects in each layer manifest as focal lamina cribrosa defects (FLDs), peripapillary intrachoroidal cavitations (PICCs), and acquired pits of the optic nerve (APON). Anterior vitreous/vascular traction and posterior scleral protrusion may lead to prelaminar schisis as well as paravascular cysts and holes, which can potentially develop into retinoschisis. Traditional color fundus photography (CFP) is often insufficient for visualizing most of these lesions, yet their description and quantification benefit significantly from the advancements in optical coherence tomography (OCT) and OCT angiography (OCTA), complemented by fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and three-dimensional imaging. The effective diagnosis and classification of ONH abnormalities heavily rely on a comprehensive understanding of their multimodal imaging features, as outlined in this review. These findings provide valuable insights into optic neuropathy in high myopia, establishing a solid foundation for future endeavors in disease monitoring and treatment guidance.
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