Evidence map›Paper›PMID 38715646›Full record

ArticleRespirology case reports2024

Effective management of lung spindle cell carcinoma with ipilimumab, nivolumab, carboplatin, and paclitaxel, demonstrating efficacy in brain metastases treatment.

Susumu Noguchi, Atsushi Okamoto, Jun Nohara, Manabu Ishitoko, Toshiki Watanabe, Takaya Nakamura

Abstract readCase Reports
In one paragraph

Article in Respirology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Susumu NoguchiRespiratory Medicine Shiga General Hospital Moriyama Japan.ORCID https://orcid.org/0000-0002-0358-4019
Atsushi OkamotoRespiratory Medicine Shiga General Hospital Moriyama Japan.
Jun NoharaRespiratory Medicine Shiga General Hospital Moriyama Japan.
Manabu IshitokoRespiratory Medicine Shiga General Hospital Moriyama Japan.
Toshiki WatanabeRespiratory Medicine Shiga General Hospital Moriyama Japan.
Takaya NakamuraRespiratory Medicine Shiga General Hospital Moriyama Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 76-year-old woman with cT1bN2M1b stage IVA spindle cell carcinoma of the right lower lobe of the lung, no driver gene mutation, and programmed death ligand 1 < 1%, was started on ipilimumab+nivolumab+carboplatin+paclitaxel. After two courses, the patient initiated maintenance therapy with ipilimumab+nivolumab. New multiple brain metastases were observed during treatment but resolved with continued treatment. We report a unique case of spindle cell carcinoma treated with ipilimumab+nivolumab+carboplatin+paclitaxel that resulted in long-term response and resolution of new brain metastasis.

Indexed as

brain metastasisipilimumablung cancernivolumabspindle cell carcinoma

Identifiers

PMID38715646
PMCPMC11076139

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.