ArticleAnalytical science advances2022
Biomimetic chromatography-A novel application of the chromatographic principles.
Article in Analytical science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Characterization of a liposome electrokinetic capillary chromatography system for surrogation of cell membrane partitions.Analytical and bioanalytical chemistry · 2026Article
- Article
- Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents.ChemMedChem · 2026Article
- Machine Learning-Driven QSRR Modeling of Albumin Binding in Fluoroquinolones: An SVR Approach Supported by HSA Chromatography.International journal of molecular sciences · 2026Article
- Ultrasound-Assisted Synthesis and Biological Profiling of 1,3,5-Triazine Derivatives with Antiproliferative Activity in Triple-Negative Breast Cancer.Current issues in molecular biology · 2026Article
- Integrated Biomimetic 2D-LC and PermeapadMolecules (Basel, Switzerland) · 2026Article
- Modelling an alternative lipophilicity scale of bisphenols using biomimetic chromatography: Relevance to membrane-driven baseline toxicity.ADMET & DMPK · 2026Article
- Experimentally derived biomimetic chromatographic descriptors for drug-induced phospholipidosis liability prediction.ADMET & DMPK · 2026Article
- Prediction of bile salt export pump inhibition using biomimetic chromatographic descriptors: Integrating membrane affinity and protein binding.ADMET & DMPK · 2026Article
- Linking biomimetic binding measurements to pharmacokinetic models of volume of distribution and hepatic clearance.ADMET & DMPK · 2026Review
- Biomimetic Chromatography as a High-Throughput Tool for Screening Bioaccumulation and Acute Aquatic Toxicity of Pesticides.Journal of xenobiotics · 2025Article
- Interactions of Epinephrine and Norepinephrine with Intralipid Emulsion Studied by Capillary Electrokinetic Chromatography.Journal of separation science · 2025Article
- Application of Biomimetic Chromatography and QSRR Approach for Characterizing Organophosphate Pesticides.International journal of molecular sciences · 2025Article
- Deriving Membrane-Water and Protein-Water Partition Coefficients from In Vitro Experiments for Per- and Polyfluoroalkyl Substances (PFAS).Environmental science & technology · 2025Article
- Different chromatographic techniques and recent advancements for biomedical and pharmaceutical applications.Northern clinics of Istanbul · 2025Article
- Mechanistic Insights into the Neurotoxicity of 2,5-Dimethoxyphenethylamines (2C) and CorrespondingJournal of xenobiotics · 2024Article
- Evaluation of Physicochemical Properties of Ipsapirone Derivatives Based on Chromatographic and Chemometric Approaches.Molecules (Basel, Switzerland) · 2024Article
- Predicting the acute aquatic toxicity of organic UV filters used in cosmetic formulations.ADMET & DMPK · 2024Article
- Biomimetic Dispersive Solid-Phase Microextraction: A Novel Concept for High-Throughput Estimation of Human Oral Absorption of Organic Compounds.Analytical chemistry · 2023Article
- Immobilized Keratin HPLC Stationary Phase-A Forgotten Model of Transdermal Absorption: To What Molecular and Biological Properties Is It Relevant?Pharmaceutics · 2023Article
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Abstract
Biomimetic chromatography is the name of the High Performance Liquid Chromatography (HPLC) methods that apply stationary phases containing proteins and phospholipids that can mimic the biological environment where drug molecules distribute. The applied mobile phases are aqueous organic with a pH of 7.4 to imitate physiological conditions that would be encountered in the human body. The calibrated retention of molecules on biomimetic stationary phases reveals a compound's affinity to proteins and phospholipids, which can be used to model the biological and environmental fate of molecules. This technology, when standardised, enables the prediction of in vivo partition and distribution behaviour of compounds and aids the selection of the best compounds for further studies to become a drug molecule. Applying biomimetic chromatographic measurements helps reduce the number of animal experiments during the drug discovery process. New biomimetic stationary phases, such as sphingomyelin and phosphatidylethanolamine, widen the application to the modelling of blood-brain barrier distribution and lung tissue binding. Recently, the measured properties have also been used to predict toxicity, such as phospholipidosis and cardiotoxicity. The aquatic toxicity of drugs and pesticides can be predicted using biomimetic chromatographic data. Biomimetic chromatographic separation methods may also be extended in the future to predict protein and receptor binding kinetics. The development of new biomimetic stationary phases and new prediction models will further accelerate the widespread application of this analytical method.
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