ArticleMicrobiome2024
Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks.
Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- The Critical Period Microbiota Shape Brain Plasticity.Research square · 2026Article
- Protective Effects and Potential Mechanisms ofAnimals : an open access journal from MDPI · 2026Article
- The Critical Period Microbiota Shape Brain Plasticity.bioRxiv : the preprint server for biology · 2026Article
- FMT from IBS-D Rats Impairs Intestinal Barrier Function and is Associated with Increased Intestinal Benzoic Acid andJournal of microbiology and biotechnology · 2026Article
- Antibiotic-induced gut microbiome dysbiosis: risks and strategies for mitigation.The EMBO journal · 2026Review
- Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms ofBiomolecules · 2026Article
- Surfactin from Bacillus subtilis 1-4 disrupts the cell membrane of zoonotic Staphylococcus intermedius in vitro and maintains gut microbiota community in urban pigeons.Gut pathogens · 2026Article
- Damage and recovery of artificial diet rearing silkworms (Bombyx mori L.) exposed to high-concentration florfenicol as well as the dynamic changes of midgut flora after functional bacterium supplementation.BMC microbiology · 2026Article
- Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Multi-Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice.Aging cell · 2026Article
- Trained immunity in respiratory diseases: Mechanisms of action and intervention strategies.Chinese medical journal pulmonary and critical care medicine · 2026Review
- The interplay between malnutrition, persistent diarrhea, lactose intolerance, and food associated gut dysbiosis in children; a comprehensive review.BMC pediatrics · 2026Review
- Assessing whether rectal swabs reflect appendiceal microbiota profiles in acute appendicitis: a 16S rRNA-based comparative study.Gut pathogens · 2026Article
- The impact of antibiotic exposure on obesity and metabolic phenotypes via the gut microbiota.Frontiers in microbiology · 2026Review
- Persistent gut microbiota dysbiosis and metabolic remodeling after ceftriaxone exposure in mice: a cross-study re-analysis.Frontiers in cellular and infection microbiology · 2026Article
- Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026Review
- Antibiotic: a boon to mankind and doom to the environment - an insight on biological and non-biological degradation processes.Frontiers in microbiology · 2026Review
- Characteristics and longitudinal stability of Gut Microbiota in healthy individuals across different age groups.Current research in microbial sciences · 2026Article
- Microbiome-Driven Risk Stratification and Biotherapeutics in Radiation Enteritis.Computational and structural biotechnology journal · 2026Review
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Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundAntibiotic exposure can occur in medical settings and from environmental sources. Long-term effects of brief antibiotic exposure in early life are largely unknown.
resultsPost a short-term treatment by ceftriaxone to C57BL/6 mice in early life, a 14-month observation was performed using 16S rRNA gene-sequencing technique, metabolomics analysis, and metagenomics analysis on the effects of ceftriaxone exposure. Firstly, the results showed that antibiotic pre-treatment significantly disturbed gut microbial α and β diversities (P < 0.05). Both Chao1 indices and Shannon indices manifested recovery trends over time, but they didn't entirely recover to the baseline of control throughout the experiment. Secondly, antibiotic pre-treatment reduced the complexity of gut molecular ecological networks (MENs). Various network parameters were affected and manifested recovery trends over time with different degrees, such as nodes (P < 0.001, R
conclusionsThese results suggest that short-term antibiotic exposure in early life will cause long-term negative impacts on gut microbial diversity, MENs, and microbial metabolism. Therefore, great concern should be raised about children's brief exposure to antibiotics if the results observed in mice are applicable to humans. Video Abstract.
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