Evidence map›Paper›PMID 38714857›Full record

ReviewNature reviews. Urology2024

Current and emerging strategies to curb antibiotic-resistant urinary tract infections.

Aaron Simoni, Laura Schwartz, Guillermo Yepes Junquera, Christina B Ching, John David Spencer

Abstract readReview
In one paragraph

Review in Nature reviews. Urology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Therapeutic strategies for multi-resistantJAC-antimicrobial resistance · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aaron SimoniThe Kidney and Urinary Tract Center, Nationwide Children's Abigail Wexner Research Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0657-3737
Laura SchwartzThe Kidney and Urinary Tract Center, Nationwide Children's Abigail Wexner Research Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-4056-3030
Guillermo Yepes JunqueraDepartment of Pediatrics, Division of Infectious Diseases, Nationwide Children's, Columbus, OH, USA.
Christina B ChingThe Kidney and Urinary Tract Center, Nationwide Children's Abigail Wexner Research Institute, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-3396-4215
John David SpencerThe Kidney and Urinary Tract Center, Nationwide Children's Abigail Wexner Research Institute, Columbus, OH, USA. John.Spencer@nationwidechildrens.org.ORCID http://orcid.org/0000-0001-5509-7135

Funding

The Contributions of Ribonuclease 4 & 7 to Urinary Tract Antibacterial DefenseR01DK115737 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI John David Spencer · 2018 to 2026
$2.8M
Insulin Signaling Activates Urothelial Defenses to Reduce Urinary Tract Infection SusceptibilityR01DK128088 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SPENCER, JOHN DAVID · 2021 to 2025
$2.6M
Linking Insulin Signaling to Antimicrobial Peptide Production and the Kidney's Antibacterial DefensesR01DK114035 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SPENCER, JOHN DAVID · 2018 to 2021
$1.4M
Urothelial IL-6 Signaling in the Host Defense Against Urinary Tract InfectionsK08DK122119 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CHING, CHRISTINA B · 2019 to 2023
$891k
NIDDK NIH HHS K08 DK122119NIDDK NIH HHS R01 DK114035NIDDK NIH HHS R01 DK115737NIDDK NIH HHS R01 DK128088
6 · The paper itself

Abstract

Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes and prolong hospital stays. Consequently, new strategies are needed to prevent and control the spread of antibiotic resistance in uropathogenic bacteria. Over the past two decades, sizeable clinical efforts and research advances have changed urinary tract infection (UTI) treatment and prevention strategies to conserve antibiotic use. The emergence of antimicrobial stewardship, policies from national societies, and the development of new antimicrobials have shaped modern UTI practices. Future UTI management practices could be driven by the evolution of antimicrobial stewardship, improved and readily available diagnostics, and an improved understanding of how the microbiome affects UTI. Forthcoming UTI treatment and prevention strategies could employ novel bactericidal compounds, combinations of new and classic antimicrobials that enhance bacterial killing, medications that prevent bacterial attachment to uroepithelial cells, repurposing drugs, and vaccines to curtail the rising rates of antibiotic resistance in uropathogenic bacteria and improve outcomes in people with UTI.

Indexed as

Anti-Bacterial AgentsUrinary Tract InfectionsAntimicrobial StewardshipDrug Resistance, BacterialHumansAnti-Bacterial Agents

Identifiers

PMID38714857
PMCPMC11540872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.