Evidence map›Paper›PMID 38714798›Full record

ArticleCommunications biology2024

Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.

Yazheng Di, Joel Mefford, Elior Rahmani, Jinhan Wang, Vijay Ravi, Aditya Gorla, Abeer Alwan, Tingshao Zhu, Jonathan Flint

Abstract read
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In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Yazheng DiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.ORCID 0000-0003-2483-1696
Joel MeffordDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3036-545X
Elior RahmaniDepartment of Computational Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-9017-2070
Jinhan WangDepartment of Electrical and Computer Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Vijay RaviDepartment of Electrical and Computer Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Aditya GorlaBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Abeer AlwanDepartment of Electrical and Computer Engineering, University of California Los Angeles, Los Angeles, CA, USA.
Tingshao ZhuCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, 100101, China.
Jonathan FlintDepartment of Psychiatry and Biobehavioral Sciences, Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA. JFlint@mednet.ucla.edu.ORCID 0000-0002-9427-4429

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH-122596
6 · The paper itself

Abstract

The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin).

Indexed as

Genome-Wide Association StudyLanguageAdultAsian PeopleCase-Control StudiesFemaleHumansIcelandMaleMiddle AgedPitch PerceptionPolymorphism, Single NucleotideVoice

Identifiers

PMID38714798
PMCPMC11076565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.