Evidence map›Paper›PMID 38714778›Full record

ArticleScientific reports2024

Identification of early coagulation changes associated with survival outcomes post severe burns from multiple perspectives.

Shengyu Huang, Qimin Ma, Xincheng Liao, Xi Yin, Tuo Shen, Xiaobin Liu, Wenbin Tang, Yusong Wang, Lei Wang, Haiming Xin and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shengyu Huang *Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Qimin Ma *Department of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xincheng Liao *Medical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Xi Yin *Department of Burns and Plastic Surgery, Zhangjiagang First People's Hospital, Suzhou, 215600, China.
Tuo ShenDepartment of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xiaobin LiuDepartment of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Wenbin TangDepartment of Burns, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, 510220, China.
Yusong WangICU of Burn and Trauma, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Lei WangDepartment of Burns and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Haiming XinDepartment of Burns and Plastic Surgery, The 924th Hospital of the Chinese People's Liberation Army, Guilin, 541002, China.
Xiaoliang LiDepartment of Burns and Plastic Surgery, Zhengzhou First People's Hospital, Zhengzhou, 450004, China.
Liu ChangDepartment of Burns and Plastic Surgery, the Fourth People's Hospital of Dalian, Dalian, 116031, China.
Zhaohong ChenDepartment of Burns, Fujian Medical University Union Hospital, Fuzhou, 350001, China.
Rui LiuDepartment of Burn Surgery, Heilongjiang Provincial Hospital, Harbin, 150036, China.
Choulang WuDepartment of Burns, Taizhou Hospital of Zhejiang Province, Linhai, 317000, China.
Deyun WangDepartment of Burns, Wuhan Third Hospital, Wuhan, 430060, China.
Guanghua GuoMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China. guogh2000@hotmail.com.
Feng ZhuDepartment of Critical Care Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. alexzhufeng0816@vip.sina.com.

Funding

National Key R&D Program "Stem Cell and Transformation Research" Key Special Project 2019YFA0110601National Natural Science Foundation of China 81701899National Natural Science Foundation of China 82160376The Top-level Clinical Discipline Project of Shanghai Pudong PWYgf2021-03
6 · The paper itself

Abstract

Coagulation alterations manifest early after severe burns and are closely linked to mortality outcomes. Nevertheless, the precise characterization of coagulation changes associated with early mortality remains elusive. We examined alterations in indicators linked to mortality outcomes at both the transcriptomic and clinical characteristic levels. At the transcriptomic level, we pinpointed 28 differentially expressed coagulation-related genes (DECRGs) following burn injuries and endeavored to validate their causal relationships through Mendelian randomization. DECRGs tied to survival exhibit a significant association with neutrophil function, wherein the expression of CYP4F2 and P2RX1 serves as robust predictors of fatal outcomes. In terms of clinical indicators, early levels of D-dimer and alterations in serum calcium show a strong correlation with mortality outcomes. Coagulation depletion and fibrinolytic activation, stemming from the hyperactivation of coagulation pathways post-severe burns, are strongly linked to patient mortality. Monitoring these early coagulation markers with predictive value can effectively identify individuals necessitating priority critical care.

Indexed as

Blood CoagulationBurnsAdultBiomarkersCalciumFemaleFibrin Fibrinogen Degradation ProductsHumansMaleMendelian Randomization AnalysisMiddle AgedTranscriptomeBiomarkersCalciumFibrin Fibrinogen Degradation Productsfibrin fragment D

Identifiers

PMID38714778
PMCPMC11076290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.