ArticleNPJ digital medicine2024
Online cognitive monitoring technology for people with Parkinson's disease and REM sleep behavioural disorder.
Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Innovative technologies to address neglected tropical diseases in African settings with persistent sociopolitical instability.Nature communications · 2024Pooled it
- Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions.Annals of clinical and translational neurology · 2026Article
- Development and Preliminary Validation of ORCA-PD, an Online Rapid Cognitive Assessment for Parkinson Disease: Mixed Methods Study.Journal of medical Internet research · 2026Article
- Validation of the comprehensive online sleep monitoring scale in a large population sample.Frontiers in psychology · 2026Article
- A comprehensive guide to digital neurology. An update on current development on digital neurology derived from the Digital Neuro Hub project.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Large-scale online assessment uncovers a distinct Multiple Sclerosis subtype with selective cognitive impairment.Nature communications · 2025Article
- Naturalistic use of psychedelics is associated with longitudinal improvements in anxiety and depression during global crisis times.Journal of psychopharmacology (Oxford, England) · 2025Article
- From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease.Molecular neurodegeneration · 2025Review
- Enhancing neuropsychological assessment clinical pathways in Parkinson's disease through the use of technology.Frontiers in digital health · 2025Article
- Cognitive and psychiatric symptom trajectories 2-3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK.The lancet. Psychiatry · 2024Article
- Metacognitive accuracy differences in Parkinson's disease and REM sleep behavioral disorder relative to healthy controls.Frontiers in neurology · 2024Article
- Online46: Online cognitive assessments in elderly cohorts-The British 1946 birth cohort case study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Automated online cognitive assessments are set to revolutionise clinical research and healthcare. However, their applicability for Parkinson's Disease (PD) and REM Sleep Behavioural Disorder (RBD), a strong PD precursor, is underexplored. Here, we developed an online battery to measure early cognitive changes in PD and RBD. Evaluating 19 candidate tasks showed significant global accuracy deficits in PD (0.65 SD, p = 0.003) and RBD (0.45 SD, p = 0.027), driven by memory, language, attention and executive underperformance, and global reaction time deficits in PD (0.61 SD, p = 0.001). We identified a brief 20-min battery that had sensitivity to deficits across these cognitive domains while being robust to the device used. This battery was more sensitive to early-stage and prodromal deficits than the supervised neuropsychological scales. It also diverged from those scales, capturing additional cognitive factors sensitive to PD and RBD. This technology offers an economical and scalable method for assessing these populations that can complement standard supervised practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.