Evidence map›Paper›PMID 38714735›Full record

ArticleNature communications2024

SARS-CoV-2 M

Patrick Y A Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker and 45 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.Protein science : a publication of the Protein Society · 2026
    Article
  3. Uncovering the covalent inhibitors of SARS-CoV-2 MJournal of pharmaceutical analysis · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Patrick Y A Reinke *Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7354-0839
Robin Schubert *European XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-6213-2872
Dominik OberthürCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-0894-9590
Marina GalchenkovaCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Aida Rahmani MashhourCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9177-5589
Sebastian GüntherCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7329-6653
Anaïs ChretienEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-8480-1443
Adam RoundEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-0723-8228
Brandon Charles SeychellInstitute of Physical Chemistry, Department of Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.
Brenna Norton-BakerMax Plank Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, 22761, Hamburg, Germany.
Chan KimEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0003-4559-7982
Christina SchmidtEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-6662-1294
Faisal H M KouaEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-8371-9587
Alexandra TolstikovaCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Wiebke EwertCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-8626-4864
Gisel Esperanza Peña MurilloCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7842-4987
Grant MillsEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Henry KirkwoodEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-6792-3844
Hévila BrognaroInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Department of Chemistry, Universität Hamburg, Build. 22a, c/o DESY, Notkestr. 85, 22607, Hamburg, Germany.
Huijong HanEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Jayanath KoliyaduEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-0245-3842
Joachim SchulzEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-9310-8832
Johan BieleckiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-3012-603X
Julia LieskeCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5439-5082
Julia MarackeCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Juraj KnoskaCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7258-6256
Kristina LorenzenEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Lea BringsEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Marcin SikorskiEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0009-0008-1243-4785
Marco KloosEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-8745-9740
Mohammad VakiliCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Patrik VagovicCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Philipp MiddendorfCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5243-8384
Raphael de WijnEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-8342-1008
Richard BeanEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-8151-7439
Romain LetrunEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-0569-5193
Seonghyun HanEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Sven FalkeCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-3409-1791
Tian GengSosei Heptares, Steinmetz Building, Granta Park, Great Abington, CB21 6DG, Cambridge, UK.
Tokushi SatoEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Vasundara SrinivasanInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Department of Chemistry, Universität Hamburg, Build. 22a, c/o DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8895-5885
Yoonhee KimEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.
Oleksandr M YefanovCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Luca GelisioEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-7832-6201
Tobias BeckInstitute of Physical Chemistry, Department of Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7398-3982
Andrew S DoréSosei Heptares, Steinmetz Building, Granta Park, Great Abington, CB21 6DG, Cambridge, UK.
Adrian P MancusoEuropean XFEL GmbH, Holzkoppel 4, 22869, Schenefeld, Germany.ORCID http://orcid.org/0000-0003-1710-8969
Christian BetzelInstitute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Department of Chemistry, Universität Hamburg, Build. 22a, c/o DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-3879-5019
Saša BajtCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7163-7602
Lars RedeckeInstitute of Biochemistry, Universität zu Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.ORCID http://orcid.org/0000-0002-5938-9431
Henry N ChapmanCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-4655-1743
Alke MeentsCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-6078-4095
Dušan TurkJožef Stefan Institute, Jamova cesta 39, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0003-0205-6609
Winfried HinrichsUniversität Greifswald, Institute of Biochemistry, Felix-Hausdorff-Str. 4, 17489, Greifswald, Germany.ORCID http://orcid.org/0000-0002-0435-4565
Thomas J LaneCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany. thomas.lane@desy.de.ORCID http://orcid.org/0000-0003-2627-4432

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 05K19GU4Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 05K20GUBDeutsche Forschungsgemeinschaft (German Research Foundation) EXC 2056 - project ID 390715994Helmholtz Association FISCOVHelmholtz Association FragXHelmholtz Association HIR3X
6 · The paper itself

Abstract

The main protease (M

Indexed as

Catalytic DomainCoronavirus 3C ProteasesCysteineDisulfidesOxidation-ReductionSARS-CoV-2COVID-19Crystallography, X-RayHumansModels, MolecularProtein Multimerization3C-like proteinase, SARS-CoV-2Coronavirus 3C ProteasesCysteineDisulfides

Identifiers

PMID38714735
PMCPMC11076503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.