Evidence map›Paper›PMID 38714691›Full record

ArticleNature communications2024

Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice.

Ashley A Keiser, Tri N Dong, Enikö A Kramár, Christopher W Butler, Siwei Chen, Dina P Matheos, Jacob S Rounds, Alyssa Rodriguez, Joy H Beardwood, Agatha S Augustynski and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ashley A KeiserDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0003-4042-0336
Tri N DongDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0001-6788-5569
Enikö A KramárDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Christopher W ButlerInstitute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, Irvine, CA, 92697, USA.
Siwei ChenInstitute for Genomics and Bioinformatics, School of Information and Computer Science, University of California, Irvine, Irvine, CA, 92697, USA.
Dina P MatheosDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Jacob S RoundsDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Alyssa RodriguezDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Joy H BeardwoodDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0002-9879-4931
Agatha S AugustynskiDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Ameer Al-ShammariDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Yasaman AlaghbandDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Vanessa Alizo VeraDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0002-4561-2495
Nicole C BerchtoldInstitute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, Irvine, CA, 92697, USA.
Sharmin ShanurDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Pierre BaldiInstitute for Genomics and Bioinformatics, School of Information and Computer Science, University of California, Irvine, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0001-8752-4664
Carl W CotmanInstitute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, Irvine, CA, 92697, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA. mwood@uci.edu.

Funding

Mechanisms of maladaptive memory formation and suppression in a preclinical model of the comorbidity between PTSD and addictionR01DA047981 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI LATTAL, K MATTHEW, WOOD, MARCELO ANDRES · 2019 to 2023
$3.7M
Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brainR01AG076835 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Marcelo Andres Wood · 2022 to 2026
$3.6M
Epigenetic mechanisms in the medial habenula governing drug-seeking behaviorR01DA047441 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2020 to 2024
$3.3M
Exercise-induced epigenetic mechanisms underlying neuronal plasticity and cognitionR01AG051807 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI COTMAN, CARL WAYNE, WOOD, MARCELO ANDRES · 2016 to 2020
$3.1M
Bioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4M
Identifying a physiological basis for accelerated memory and synaptic plasticity vulnerability in females with AD pathologyR21AG067613 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI OBENAUS, ANDRE, WOOD, MARCELO ANDRES · 2020 to 2020
$432k
Delineating how epigenetic regulation of ACVR1C contributes to age and AD-related memory impairments in females and malesK99AG078501 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEISER, ASHLEY A · 2022 to 2023
$219k
Determining how the epigenome serves as the interface between exercise and facilitated memory formation in the adult and aging female and male brainF32AG071209 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEISER, ASHLEY A · 2021 to 2021
$66k
Epigenetic Mechanisms Underlying Drug-seeking Behavior: Role of HDAC3 in Regulating Gene Expression within the MHb Cholinergic Population for Cocaine-induced Relapse-like BehaviorF31DA059982 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI ALIZO VERA, VANESSA · 2024 to 2024
$45k
NIA NIH HHS F32 AG071209NIA NIH HHS K99 AG078501NIA NIH HHS R01 AG051807NIA NIH HHS R01 AG076835NIA NIH HHS R21 AG067613NIDA NIH HHS F31 DA059982NIDA NIH HHS R01 DA047441NIDA NIH HHS R01 DA047981NIGMS NIH HHS R01 GM123558
6 · The paper itself

Abstract

Exercise has beneficial effects on cognition throughout the lifespan. Here, we demonstrate that specific exercise patterns transform insufficient, subthreshold training into long-term memory in mice. Our findings reveal a potential molecular memory window such that subthreshold training within this window enables long-term memory formation. We performed RNA-seq on dorsal hippocampus and identify genes whose expression correlate with conditions in which exercise enables long-term memory formation. Among these genes we found Acvr1c, a member of the TGF ß family. We find that exercise, in any amount, alleviates epigenetic repression at the Acvr1c promoter during consolidation. Additionally, we find that ACVR1C can bidirectionally regulate synaptic plasticity and long-term memory in mice. Furthermore, Acvr1c expression is impaired in the aging human and mouse brain, as well as in the 5xFAD mouse model, and over-expression of Acvr1c enables learning and facilitates plasticity in mice. These data suggest that promoting ACVR1C may protect against cognitive impairment.

Indexed as

Activin Receptors, Type IEpigenesis, GeneticHippocampusMemory, Long-TermPhysical Conditioning, AnimalAgingAnimalsFemaleHumansMaleMiceMice, Inbred C57BLNeuronal PlasticityPromoter Regions, GeneticActivin Receptors, Type IAcvr1 protein, mouse

Identifiers

PMID38714691
PMCPMC11076285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.