Evidence map›Paper›PMID 38714562›Full record

ArticleArchives of gynecology and obstetrics2024

Association between BMI and oncologic outcomes in epithelial ovarian cancer: a predictors-matched case-control study.

Gabriel Levin, Yoav Brezinov, Yossi Tzur, Tomer Bar-Noy, Melica Nourmoussavi Brodeur, Shannon Salvador, Susie Lau, Walter Gotlieb

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Article in Archives of gynecology and obstetrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Association between body mass index, obesity, and vulvar cancer recurrence.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Gabriel LevinDivision of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada. gabriel.levin2@mail.mcgill.ca.ORCID 0000-0003-1282-5379
Yoav BrezinovSegal Cancer Center, Lady Davis Institute of Medical Research, McGill University, Montreal, QC, Canada.
Yossi TzurSegal Cancer Center, Lady Davis Institute of Medical Research, McGill University, Montreal, QC, Canada.
Tomer Bar-NoySegal Cancer Center, Lady Davis Institute of Medical Research, McGill University, Montreal, QC, Canada.
Melica Nourmoussavi BrodeurDivision of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Shannon SalvadorDivision of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Susie LauDivision of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Walter GotliebDivision of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to study the association between obesity and survival in ovarian cancer (OC) patients, accounting for confounders as disease stage, histology, and comorbidities.

methodsRetrospective matched case-control study of consecutive patients, with epithelial OC. Obese (body mass index [BMI] ≥ 35 kg m

resultsOverall, 153 consecutive patients were included, of whom 32 (20.9%) had a BMI ≥ 35. and 121 a BMI < 35. The median follow-up time was 39 months (interquartile range 18-67). Both study groups were similar in multiple prognostic factors, including American Society of Anesthesiologists physical status, completion of cytoreduction, histology and stage of disease (p = 0.981, p = 0.992, p = 0.740 and p = 0.984, respectively). Ninety-five (62.1%) patients underwent robotic surgery and conversion rate from robotic to laparotomy was similar in both groups 2 (6.3%) in obese group vs. 6 (5.0%) in lower BMI patients, p = 0.673. During the follow-up time, the rate of recurrence was similar in both groups; 21 (65.6%) in obese group vs. 68 (57.1%), p = 0.387 and the rate of death events was similar; 16 (50.0%) in obese group vs. 49 (40.5%), p = 0.333). The 3-year OS was higher in the obese group (log rank p = 0.042) but the 3-year RFS was similar in both groups (log rank p = 0.556). Median total OS was similar in both groups 62 months (95% confidence interval 25-98 months) in obese vs. 67 months (95% confidence interval 15-118) in the lower BMI group, log rank p = 0.822. Median RFS was similar in both groups; 61 months (95% confidence interval 47-74) in obese, vs. 54 (95% confidence interval 43-64), log rank p = 0.842. In Cox regression analysis for OS, including obesity, age, laparotomy and neoadjuvant treatment - only neoadjuvant treatment was independently associated with longer OS: odds ratio 1.82 (95% confidence interval 1.09-3.05) and longer RFS: odds ratio 2.16 (95% confidence interval 1.37-3.41).

conclusionsIn the present study on consecutive cases of ovarian cancer, obesity did not seem to be associated with outcome, except for an apparent improved 3-year survival that faded away thereafter.

Indexed as

Body Mass IndexCarcinoma, Ovarian EpithelialObesityOvarian NeoplasmsAdultAgedCase-Control StudiesCytoreduction Surgical ProceduresDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasm StagingProportional Hazards ModelsRetrospective StudiesCase-controlMatchedObesityOvarian cancerSurvival

Identifiers

PMID38714562
PMCPMC11168986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.