Evidence map›Paper›PMID 38714198›Full record

ArticleCell reports methods2024

Optimizing the conversion of phosphoenolpyruvate to lactate by enzymatic channeling with mixed nanoparticle display.

Shelby L Hooe, Christopher M Green, Kimihiro Susumu, Michael H Stewart, Joyce C Breger, Igor L Medintz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shelby L HooeCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Christopher M GreenCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Kimihiro SusumuOptical Sciences Division Code 5611, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Michael H StewartOptical Sciences Division Code 5611, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Joyce C BregerCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Igor L MedintzCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA. Electronic address: igor.medintz@nrl.navy.mil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Co-assembling enzymes with nanoparticles (NPs) into nanoclusters allows them to access channeling, a highly efficient form of multienzyme catalysis. Using pyruvate kinase (PykA) and lactate dehydrogenase (LDH) to convert phosphoenolpyruvic acid to lactic acid with semiconductor quantum dots (QDs) confirms how enzyme cluster formation dictates the rate of coupled catalytic flux (k

Indexed as

Lactic AcidL-Lactate DehydrogenaseNanoparticlesPhosphoenolpyruvatePyruvate KinaseKineticsQuantum DotsLactic AcidL-Lactate DehydrogenasePhosphoenolpyruvatePyruvate KinasebionanotechnologycascadeCP: biotechnologydiffusionenzymenanoparticlequantum dotsubstrate channelingsynthetic biology, biocatalysis

Identifiers

PMID38714198
PMCPMC11133815

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.