ArticleJMIR public health and surveillance2024
Association of Rest-Activity Rhythm and Risk of Developing Dementia or Mild Cognitive Impairment in the Middle-Aged and Older Population: Prospective Cohort Study.
Article in JMIR public health and surveillance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between circadian rhythm disturbances and cognitive decline in the elderly: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- AI and Wearables for Early Detection of Cognitive Impairment and Dementia: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Article
- Enhancing a Behavioral Intervention Using Rest-Activity Rhythm Monitoring via a Consumer Wearable in Older Dementia Caregivers and People With Dementia: Feasibility and Acceptability Study.JMIR formative research · 2026Article
- Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study.medRxiv : the preprint server for health sciences · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- UK Biobank at 20 - a growing, global resource for dementia research.Nature reviews. Neurology · 2026Review
- Circadian Regulation and Pain: A Systematic Review of the Association Between Rest-Activity Rhythm and Pain-Related Outcomes.Clocks & sleep · 2026Review
- Characterizing circadian rest-activity rhythm patterns across Alzheimer's disease continuum in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of physical activity and rest-activity rhythm with sustained attention and melatonin among community-dwelling older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- AI-enabled digital phenotyping for Alzheimer's disease: a review of multimodal sensor integration and symptom trajectories.Alzheimer's research & therapy · 2026Review
- From mouth to muscle: mechanistic and interventional perspectives on the tongue-coating microbiome in sarcopenia.Journal of translational medicine · 2026Review
- Control vs. salience: a new axis of circadian brain-body organization.Npj biological timing and sleep · 2026Article
- Proteins at the intersection of circadian rhythms and metabolic dysfunction-associated steatotic liver disease: an 18-protein panel as a novel predictive biomarker set.Frontiers in endocrinology · 2026Article
- Sleep Rhythmicity as a Core Domain of Multidimensional Sleep Health Associated with Cognitive Impairment in Older Men.Nature and science of sleep · 2026Article
- Exercise timing as a potential temporal regulator of neurolymphatic physiology in neurodegenerative proteinopathies: a mechanistic framework.Frontiers in neuroscience · 2026Review
- Longitudinal associations of rest-activity rhythms with executive function, plasma biomarkers, and clinical outcomes in older adults.Frontiers in aging neuroscience · 2026Article
- Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Beyond FITT: addressing density in understanding the dose-response relationships of physical activity with health-an example based on brain health.European journal of applied physiology · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe relationship between 24-hour rest-activity rhythms (RARs) and risk for dementia or mild cognitive impairment (MCI) remains an area of growing interest. Previous studies were often limited by small sample sizes, short follow-ups, and older participants. More studies are required to fully explore the link between disrupted RARs and dementia or MCI in middle-aged and older adults.
objectiveWe leveraged the UK Biobank data to examine how RAR disturbances correlate with the risk of developing dementia and MCI in middle-aged and older adults.
methodsWe analyzed the data of 91,517 UK Biobank participants aged between 43 and 79 years. Wrist actigraphy recordings were used to derive nonparametric RAR metrics, including the activity level of the most active 10-hour period (M10) and its midpoint, the activity level of the least active 5-hour period (L5) and its midpoint, relative amplitude (RA) of the 24-hour cycle [RA=(M10-L5)/(M10+L5)], interdaily stability, and intradaily variability, as well as the amplitude and acrophase of 24-hour rhythms (cosinor analysis). We used Cox proportional hazards models to examine the associations between baseline RAR and subsequent incidence of dementia or MCI, adjusting for demographic characteristics, comorbidities, lifestyle factors, shiftwork status, and genetic risk for Alzheimer's disease.
resultsDuring the follow-up of up to 7.5 years, 555 participants developed MCI or dementia. The dementia or MCI risk increased for those with lower M10 activity (hazard ratio [HR] 1.28, 95% CI 1.14-1.44, per 1-SD decrease), higher L5 activity (HR 1.15, 95% CI 1.10-1.21, per 1-SD increase), lower RA (HR 1.23, 95% CI 1.16-1.29, per 1-SD decrease), lower amplitude (HR 1.32, 95% CI 1.17-1.49, per 1-SD decrease), and higher intradaily variability (HR 1.14, 95% CI 1.05-1.24, per 1-SD increase) as well as advanced L5 midpoint (HR 0.92, 95% CI 0.85-0.99, per 1-SD advance). These associations were similar in people aged <70 and >70 years, and in non-shift workers, and they were independent of genetic and cardiovascular risk factors. No significant associations were observed for M10 midpoint, interdaily stability, or acrophase.
conclusionsBased on findings from a large sample of middle-to-older adults with objective RAR assessment and almost 8-years of follow-up, we suggest that suppressed and fragmented daily activity rhythms precede the onset of dementia or MCI and may serve as risk biomarkers for preclinical dementia in middle-aged and older adults.
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