ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of risk factors for vascular dementia using Mendelian randomization: a call for methodologically robust studies to advance knowledge.BMC neurology · 2026Pooled it
- Stage-specific effects of early-life tobacco exposure on mental health, inflammation, and brain structure-function coupling.Translational psychiatry · 2026Article
- Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.Translational psychiatry · 2026Article
- Maternal Smoking during Pregnancy, Smoking Initiation, and the Risk of Epilepsy in the UK Biobank.Neuroepidemiology · 2026Article
- Maternal smoking during pregnancy in relation to adolescent anxiety and poor mental health: A cross-sectional study based on NHANES 2007-2012.Tobacco induced diseases · 2026Article
- A Genome-wide study on the genetic and causal effects of smoking in neurodegeneration.Journal of translational medicine · 2025Article
- Regional variability of the impact of cardiometabolic diseases on incident dementia in United States Medicare beneficiaries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- The Lung-Brain Axis in Chronic Obstructive Pulmonary Disease-Associated Neurocognitive Dysfunction: Mechanistic Insights and Potential Therapeutic Options.International journal of biological sciences · 2025Review
- Global, regional, and national disease burden of tobacco-related Alzheimer's disease among individuals over the age of 55: a global burden of disease study.Frontiers in public health · 2025Article
- The impact of maternal smoking during pregnancy and the age of smoking initiation on incident dementia: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThe impact of early-life tobacco exposure on dementia has remained unknown.
methodsUsing the UK Biobank, the associations of maternal smoking during pregnancy (MSDP) and age of smoking initiation (ASI) with the onset time of all-cause dementia were estimated with accelerated failure time models. The effects of MSDP and ASI on brain structure and their genetic correlation to Alzheimer's disease (AD) were analyzed. A Mendelian randomization (MR) analysis was conducted.
resultsThe time ratios for smokers starting in childhood, adolescence, and adulthood (vs never smokers) were 0.87 (0.76 to 0.99), 0.92 (0.88 to 0.96), and 0.95 (0.89 to 1.01). MSDP and smoking in adolescence altered many brain regions, including the hippocampus. In genetic analysis, MSDP was genetically and causally linked to AD, and a younger ASI was genetically correlated to a higher AD risk. DISCUSSION: Early-life smoking accelerated dementia onset and was genetically correlated to AD. MSDP demonstrated genetic and causal linkage to AD risks. HIGHLIGHTS: Unlike the commonly used Cox proportional hazards model, this article uses a parametric survival analysis method - the accelerated failure model - to explore the relationship between exposure to onset time. It can be used as an alternative method when the proportional hazards assumption is not met. Genetic analyses including genetic correlation study and MR analysis and brain structure analyses were conducted to support our findings and explore the potential mechanisms. The study reveals the relationship between different smoking initiation periods and the onset time of dementia and shows that earlier smoking exposure has a more significant impact on dementia. It emphasizes the importance of preventing early smoking. In the future, more research focusing on the relationship between early exposure and dementia is called for to provide more detailed prevention measures for dementia that cover all age groups.
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