Evidence map›Paper›PMID 38713625›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration.

Viraj Doddihal, Frederick G Mann, Eric J Ross, Mary C McKinney, Carlos Guerrero-Hernández, Carolyn E Brewster, Sean A McKinney, Alejandro Sánchez Alvarado

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Viraj DoddihalStowers Institute for Medical Research, Kansas City, MO 64110.
Frederick G MannStowers Institute for Medical Research, Kansas City, MO 64110.
Eric J RossStowers Institute for Medical Research, Kansas City, MO 64110.
Mary C McKinneyStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-6819-1419
Carlos Guerrero-HernándezStowers Institute for Medical Research, Kansas City, MO 64110.
Carolyn E BrewsterStowers Institute for Medical Research, Kansas City, MO 64110.
Sean A McKinneyStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-9740-6247
Alejandro Sánchez AlvaradoStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-1966-6959

Funding

The molecular basis of planarian regenerationR37GM057260 · NIGMS · UNIVERSITY OF UTAH · PI SANCHEZ ALVARADO, ALEJANDRO · 2009 to 2018
$2.8M
Howard Hughes Medical Institute (HHMI) N/ANIGMS NIH HHS R37 GM057260Stowers Institute for Medical Research (SIMR) N/A
6 · The paper itself

Abstract

Successful regeneration of missing tissues requires seamless integration of positional information along the body axes. Planarians, which regenerate from almost any injury, use conserved, developmentally important signaling pathways to pattern the body axes. However, the molecular mechanisms which facilitate cross talk between these signaling pathways to integrate positional information remain poorly understood. Here, we report a

Indexed as

p21-Activated KinasesPlanariansWnt Signaling PathwayAnimalsBody PatterningNuclear ProteinsProtein Serine-Threonine KinasesRegenerationTrans-ActivatorsNuclear Proteinsp21-Activated KinasesProtein Serine-Threonine KinasesTrans-Activatorsbody axesHipporegenerationsignalingWNT

Identifiers

PMID38713625
PMCPMC11098123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.