Evidence map›Paper›PMID 38713624›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.

Xiaoyi G Liang, Kendy Hoang, Brandon L Meyerink, Pratiksha Kc, Kitt Paraiso, Li Wang, Ian R Jones, Yue Zhang, Sol Katzman, Thomas S Finn and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. NOTCH, ERK, and SHH signaling respectively control the fate determination of cortical glia and olfactory bulb interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
  9. Article
  10. A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xiaoyi G LiangDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.
Kendy HoangDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.
Brandon L MeyerinkDivision of Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104.
Pratiksha KcDivision of Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104.
Kitt ParaisoEnvironmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Li WangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143.
Ian R JonesInstitute for Human Genetics, University of California, San Francisco, CA 94143.
Yue ZhangDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.
Sol KatzmanGenome Institute, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-1787-1246
Thomas S FinnDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-4522-5321
Jeremiah TsyporinDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.
Fangyuan QuDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.
Zhaoxu ChenDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-8276-2206
Axel ViselEnvironmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Arnold KriegsteinEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143.ORCID 0000-0001-5742-2990
Yin ShenDepartment of Neurology, University of California, San Francisco, CA 94143.
Louis-Jan PilazDivision of Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104.
Bin ChenDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064.ORCID 0000-0003-1962-3593

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
Lineage Progression of Cortical Neural Stem CellsR01NS089777 · NINDS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2015 to 2025
$4.7M
A Single-Cell Resolution Enhancer Atlas of Craniofacial DevelopmentR01DE028599 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2019 to 2023
$4.2M
Transcriptional regulation of neuronal identity and connectivityR01MH094589 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHEN, BIN · 2011 to 2021
$3.7M
Linking Psychiatric Genetics to Cell-Type Specific Enhancer FunctionR01MH117106 · NIMH · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2018 to 2022
$3.6M
Charting the 3D epigenome in human brain development and diseasesU01DA052713 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRIEGSTEIN, ARNOLD, SHEN, YIN · 2020 to 2024
$3.4M
Transcriptional regulation of neural progenitor divisions and cell fate in the developing cortexR01MH129419 · NIMH · SANFORD RESEARCH/USD · PI Louis-Jan Pilaz · 2023 to 2026
$1.7M
A postdoctoral training program for impactful careers in stem cell biologyT32HD108079 · NICHD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Bin Chen, CAMILLA FORSBERG · 2022 to 2026
$1.1M
BSLII Stationed Zeiss 880 Confocal Microscope with AiryscanS10OD023528 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YILDIZ, HAVVA FITNAT · 2017 to 2017
$456k
NICHD NIH HHS T32 HD108079NIDA NIH HHS U01 DA052713NIDCR NIH HHS R01 DE028599NIGMS NIH HHS P20 GM103620NIH HHS S10 OD023528NIMH NIH HHS R01 MH094589NIMH NIH HHS R01 MH117106NIMH NIH HHS R01 MH129419NINDS NIH HHS R01 NS089777
6 · The paper itself

Abstract

During development, neural stem cells in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. We and others recently showed that Sonic Hedgehog (Shh) signaling promotes the cortical RGC lineage switch to generate cortical oligodendrocytes and OB interneurons. During this process, cortical RGCs generate intermediate progenitor cells that express critical gliogenesis genes

Indexed as

Basic Helix-Loop-Helix ProteinsCerebral CortexErbB ReceptorsHedgehog ProteinsNerve Tissue ProteinsNeural Stem CellsNeurogenesisOligodendrocyte Transcription Factor 2PAX6 Transcription FactorAnimalsCell LineageEye ProteinsGene Expression Regulation, DevelopmentalHomeodomain ProteinsHumansMiceAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsEGFR protein, mouseErbB ReceptorsEye ProteinsGli3 protein, mouseHedgehog ProteinsHomeodomain ProteinsNerve Tissue ProteinsOlig2 protein, mouseOligodendrocyte Transcription Factor 2Paired Box Transcription FactorsPAX6 protein, humanPax6 protein, mousePAX6 Transcription FactorRepressor ProteinsShh protein, mouseZinc Finger Protein Gli3enhancergliogenesislineage switchneurogenesisOlig2

Identifiers

PMID38713624
PMCPMC11098099

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.