Evidence map›Paper›PMID 38713616›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Novel 5-HT

Yun Han Kwon, Benjamin E Blass, Huaqing Wang, Jensine A Grondin, Suhrid Banskota, Kenneth Korzekwa, Min Ye, John C Gordon, Dennis Colussi, Kevin M Blattner and 2 more

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yun Han KwonFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-4232-9141
Benjamin E BlassDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Huaqing WangFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jensine A GrondinFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Suhrid BanskotaFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-3183-6268
Kenneth KorzekwaDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Min YeDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
John C GordonDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Dennis ColussiDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Kevin M BlattnerDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Daniel J CanneyDepartment of Pharmaceuticals Sciences, Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, Philadelphia, Pennsylvania, United States.
Waliul I KhanFarncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-6282-9514

Funding

Predicting Intracellular Drug Concentrations In The Presence Of TransportersR01GM104178 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Kenneth Ray Korzekwa, Swati Nagar · 2013 to 2026
$4.0M
Canadian Government | Canadian Institutes of Health Research (CIHR) PJT 156262Crohn's and Colitis Foundation (CCF) 510490NIGMS NIH HHS R01 GM104178
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) encompasses several debilitating chronic gastrointestinal (GI) inflammatory disorders, including Crohn's disease and ulcerative colitis. In both conditions, mucosal inflammation is a key clinical presentation associated with altered serotonin (5-hydroxytryptamine or 5-HT) signaling. This altered 5-HT signaling is also found across various animal models of colitis. Of the 14 known receptor subtypes, 5-HT receptor type 7 (5-HT

Indexed as

ColitisReceptors, SerotoninSerotonin AntagonistsAnimalsColonDextran SulfateDisease Models, AnimalIntestinal MucosaMaleMiceMice, Inbred C57BLSeverity of Illness IndexSignal TransductionDextran SulfateReceptors, Serotoninserotonin 7 receptorSerotonin Antagonists5-HT5-HT7 receptor5-HT7 receptor antagonistinflammatory bowel diseaseserotonin

Identifiers

PMID38713616
PMCPMC11550998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.