ArticleThe Journal of infectious diseases2024
A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections.
Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- A cross-ancestry genetic atlas of shared susceptibility between infectious diseases and cancer.Functional & integrative genomics · 2026Article
- Early life factors and genetic interactions in allergic rhinitis: a genome-wide study.BMC pediatrics · 2026Article
- Thyroid function and risk of sepsis: a population-based prospective cohort study with traditional and genetic epidemiological analyses.Frontiers in endocrinology · 2026Article
- The impact of prolonged air pollution exposure on urinary tract and male reproductive system infections: insights from a large-scale prospective cohort study.BMC public health · 2025Article
- Reply to Possenriede et al.: LDLR as a targetable HlyA receptor inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exosomal LncRNA SCAMP1-AS1 enhances osteosarcoma malignancy by regulating the LKB1-AMPK signaling pathway.Scientific reports · 2025Article
- Causal Relationship Between Intelligence, Noncognitive Education, Cognition and Urinary Tract or Kidney Infection: A Mendelian Randomization Study.International journal of nephrology and renovascular disease · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundOur goal was to identify genetic and modifiable risk factors for upper urinary tract infections (UTIs).
methodsWe used data from UK Biobank, the Trøndelag Health Study, and the Michigan Genomics Initiative to conduct genome-wide association studies and sex-stratified analyses on upper UTI. Mendelian randomization (MR) analyses were conducted to examine potential causal relationships between cardiometabolic risk factors and upper UTIs.
resultsOne genome-wide significant (P ≤ 5E-08) locus was associated with the susceptibility to upper UTI, located near TSN in the female-only analysis. Additionally, we identified suggestive (P ≤ 5E-06) loci near DNAI3 for females, SCAMP1-AS1 for males, and near TSN, LINC00603, and HLA-DQA2 for both sexes. In MR analyses, higher genetically predicted lifetime smoking scores were associated with an increased risk of developing upper UTI for females and both sexes (odds ratio [OR], 4.84, P = 4.50E-06 and OR, 2.79, P = 3.02E-05, respectively).
conclusionsWe found that genetic variants near TSN was associated with the risk of upper UTIs among females. In addition, we found several genetic loci with suggestive associations with the risk of upper UTIs. Finally, MR analyses found smoking to be a potential causal risk factor for upper UTIs.
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