Evidence map›Paper›PMID 38713393›Full record

ArticleJournal of neurology2024

Visuospatial working memory in behavioural variant frontotemporal dementia: a comparative analysis with Alzheimer's disease using the box task.

David Foxe, Muireann Irish, James Carrick, Sau Chi Cheung, Her Teng, James R Burrell, Roy P C Kessels, Olivier Piguet

Erratum issuedAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

David FoxeSchool of Psychology, The University of Sydney, Sydney, Australia. david.foxe@sydney.edu.au.ORCID http://orcid.org/0000-0003-0299-3344
Muireann IrishSchool of Psychology, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0002-4950-8169
James CarrickSchool of Psychology, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0003-1392-8919
Sau Chi CheungSchool of Psychology, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0001-5370-7219
Her TengSchool of Psychology, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0003-3828-1736
James R BurrellBrain and Mind Centre, The University of Sydney, 94 Mallett St, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0001-9638-2768
Roy P C KesselsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-9500-9793
Olivier PiguetSchool of Psychology, The University of Sydney, Sydney, Australia.ORCID http://orcid.org/0000-0002-6696-1440

Funding

Centre of Excellence in Cognition and its Disorders, Australian Research Council CE11000102Department of Health and Aged Care, Australian Government GNT2024329National Health and Medical Research Council GNT1037746National Health and Medical Research Council GNT1072451National Health and Medical Research Council GNT2008020
6 · The paper itself

Abstract

objectiveThis study investigated the visuospatial working memory profiles of behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) using a novel computerised test of visuospatial working memory: the Box Task.

methodsTwenty-eight bvFTD and 28 AD patients, as well as 32 age-matched control participants were recruited. All participants completed the Box Task and conventional neuropsychological tests of working memory, episodic memory, and visuospatial function.

resultsBoth the bvFTD and AD groups exhibited significantly more Box Task between-search errors than the control group across all set sizes. Notably, the AD group demonstrated a significantly higher error rate compared to the bvFTD group. Regression analysis revealed that whilst episodic memory impairment significantly predicted Box Task error performance in AD, this was not the case for bvFTD. Additionally, a noticeable trend was observed for attention in predicting Box Task errors in both bvFTD and AD groups. The Box Task demonstrated high utility in differentiating between bvFTD and AD, with a decision tree correctly classifying 82.1% of bvFTD patients and 75% of AD patients.

conclusionsOur findings reveal significant visuospatial working memory impairments in bvFTD, albeit of lesser severity compared to disease-matched AD patients. The Box Task, a novel measure of visuospatial working memory, proved effective in differentiating between bvFTD and AD, outperforming many traditional neuropsychological measures. Overall, our findings highlight the utility of assessing visuospatial memory when differentiating between bvFTD and AD in the clinical setting.

Indexed as

Alzheimer DiseaseFrontotemporal DementiaMemory, Short-TermNeuropsychological TestsAgedFemaleHumansMaleMemory DisordersMemory, EpisodicMiddle AgedSpace PerceptionSpatial MemoryVisual PerceptionAlzheimer’s diseaseCognitive assessmentFrontotemporal dementiaVisuospatial working memory

Identifiers

PMID38713393
PMCPMC11319587

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.