Evidence map›Paper›PMID 38713298›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

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Yong Wang, Yang Zhang, Yunhao Chen, Shijie Wang, Wei Liu, Zhiguo Liu, Man Hu

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06690216 (Evaluation of the Value of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06690216 phase1 / phase2enrolling by invitationnot on this map

Evaluation of the Value of [18F]AlF-NOTA-PCP2 PET/CT for PD-L1 Detection in Malignant Tumors

TypeinterventionalSponsorMan HuRan2024 to 2026Enrolled100ConditionsGlioblastoma (GBM), Head and Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer, Esophageal CancerArmsPET/CT ([18F]AlF-NOTA-PCP2), [18F]AlF-NOTA-PCP2 PET/CT Imaging for PD-L1 Expression in Malignant Tumors
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong WangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Yang ZhangDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Yunhao ChenDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Shijie WangDepartment of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Wei LiuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.
Zhiguo LiuDepartment of PET/CT Center, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. zgliu0704@sina.com.
Man HuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China. human5770@163.com.

Funding

China Postdoctoral Science Foundation 2023M734299Higher Educational Institutions Youth Innovation Science and Technology Support Program of Shandong Province 2023KJL004National Natural Science Foundation of China 82202958National Natural Science Foundation of China 82272751Science Technology Program of Jinan No. 202225019,No. 202225013Shandong Postdoctoral Innovation Program SDCX-ZG-202302011the foundation of Natural Science Foundation of Shandong ZR2021LSW002
6 · The paper itself

Abstract

purposeThe unsatisfactory efficacy of PD-L1 antibodies in glioblastoma (GBM) is largely due to the temporal and spatial heterogeneity of PD-L1 expression. Molecular imaging can enhance understanding of the tumor immune microenvironment and guide immunotherapy. However, highly sensitive imaging agents capable of effectively visualizing PD-L1 heterogeneity are limited. This study introduces a novel PET tracer, offering improved imaging of PD-L1 heterogeneity in GBM xenografts, with a comparative analysis to [

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conclusion[

Indexed as

B7-H1 AntigenGlioblastomaPositron Emission Tomography Computed TomographyAnimalsBrain NeoplasmsCell Line, TumorHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHumansMiceRadioactive TracersRadiopharmaceuticalsTissue Distribution1,4,7-triazacyclononane-N,N',N''-triacetic acidB7-H1 AntigenHeterocyclic CompoundsHeterocyclic Compounds, 1-RingRadioactive TracersRadiopharmaceuticalsComparative analysisHeterogeneityPD-L1PET/CT immunoimagingRadiation

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.