Evidence map›Paper›PMID 38713255›Full record

ArticleAnnals of hematology2024

Inflammation mediated angiogenesis in chronic lymphocytic leukemia.

Olivera Mitrović-Ajtić, Emilija Živković, Tijana Subotički, Miloš Diklić, Dragoslava Đikić, Milica Vukotić, Teodora Dragojević, Vojin Vuković, Darko Antić, Vladan P Čokić

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Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olivera Mitrović-Ajtić *Department of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia. oliveram@imi.bg.ac.rs.ORCID http://orcid.org/0000-0003-3977-2780
Emilija Živković *Department of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Tijana SubotičkiDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Miloš DiklićDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Dragoslava ĐikićDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Milica VukotićDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Teodora DragojevićDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.
Vojin VukovićLymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Darko AntićLymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia.
Vladan P ČokićDepartment of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, 11129, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation has been identified in leukemias as an essential regulator of angiogenesis. B-chronic lymphocytic leukemia (CLL) cells secrete high levels of vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1 alpha (HIF1α). The aim was to assess the role of inflammation in activation of angiogenic factors: endothelial nitric oxide synthase (eNOS), HIF1α and VEGF via proliferation related signaling pathways and VEGF autocrine control. We isolated mononuclear cells (MNC) and CD19

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitInflammationLeukemia, Lymphocytic, Chronic, B-CellNeovascularization, PathologicVascular Endothelial Growth Factor AAdultAgedAged, 80 and overAngiogenesisFemaleHumansInterleukin-6MaleMiddle AgedNitric Oxide Synthase Type IIISignal TransductionHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIL6 protein, humanInterleukin-6Nitric Oxide Synthase Type IIINOS3 protein, humanVascular Endothelial Growth Factor AVEGFA protein, humanAngiogenesisChronic lymphocytic leukemiaInflammationInterleukin-6Neovascularization

Identifiers

PMID38713255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.