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ArticleAnalytical and bioanalytical chemistry2024

A new green approach to L-histidine and β-alanine analysis in dietary supplements using rapid and simple contactless conductivity detection integrated with high-resolution glass-microchip electrophoresis.

Iva Pukleš, Csilla Páger, Nikola Sakač, Brunislav Matasović, Elvira Kovač-Andrić, Bojan Šarkanj, Mirela Samardžić, Mateja Budetić, Katarína Molnárová, Dean Marković and 2 more

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Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Advancement of microchip electrophoresis coupled with capacitively coupled contactless conductivity detection-from design to application (2018-2024).Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iva PuklešDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia.
Csilla PágerInstitute of Bioanalysis, Medical School, Szentágothai Research Center, University of Pécs, Pécs, Hungary.
Nikola SakačFaculty of Geotechnical Engineering, University of Zagreb, Hallerova 7, HR-42000, Varaždin, Croatia.
Brunislav MatasovićDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia.
Elvira Kovač-AndrićDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia.
Bojan ŠarkanjDepartment of Food Technology, University North, Trg dr. Žarka Dolinara 1, HR-48000, Koprivnica, Croatia.
Mirela SamardžićDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia.
Mateja BudetićDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia.
Katarína MolnárováDepartment of Analytical Chemistry, Faculty of Science, Charles University, Hlavova 8, 12843, Prague 2, Czech Republic.
Dean MarkovićDepartment of Biotechnology, University of Rijeka, Radmile Matejčić 2, HR-51000, Rijeka, Croatia.
Ana VesingerPirelli Deutschland GmbH, Höchster Straße 48-60, 64747, Breuberg, Germany.
Marija JozanovićDepartment of Chemistry, Josip Juraj Strossmayer University of Osijek, Cara Hadrijana 8, HR-31000, Osijek, Croatia. mhorvat2@kemija.unios.hr.

Funding

European Structural and Investment Funds #KK.01.1.1.01.0010
6 · The paper itself

Abstract

The analysis of dietary supplements is far less regulated than pharmaceuticals, leading to potential quality issues. Considering their positive effect, many athletes consume supplements containing L-histidine and β-alanine. A new microfluidic method for the determination of L-histidine and β-alanine in dietary supplement formulations has been developed. For the first time, capacitively coupled contactless conductivity detection was employed for the microchip electrophoresis of amino acids in real samples. A linear relationship between detector response and concentration was observed in the range of 10-100 µmol L

Indexed as

beta-AlanineDietary SupplementsElectric ConductivityElectrophoresis, MicrochipHistidineGlassGreen Chemistry TechnologyLimit of Detectionbeta-AlanineHistidineAmino acidsCapacitively coupled contactless conductivity detectionDietary supplementsl-HistidineMicrochip electrophoresisβ-Alanine

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.