Evidence map›Paper›PMID 38712889›Full record

ArticleACS infectious diseases2024

Development of a Selective and Stable Antimicrobial Peptide.

Kyra E Groover, Justin R Randall, Bryan W Davies

Abstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyra E GrooverDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-6755-820X
Justin R RandallDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Bryan W DaviesDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-2046-0341

Funding

Investigating nanobodies to target multidrug resistant bacterial pathogensR01AI148419 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI DAVIES, BRYAN WILLIAM · 2020 to 2023
$2.8M
NIAID NIH HHS R01 AI148419
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are presented as potential scaffolds for antibiotic development due to their desirable qualities including broad-spectrum activity, rapid action, and general lack of susceptibility to current resistance mechanisms. However, they often lose antibacterial activity under physiological conditions and/or display mammalian cell toxicity, which limits their potential use. Identification of AMPs that overcome these barriers will help develop rules for how this antibacterial class can be developed to treat infection. Here we describe the development of our novel synthetic AMP, from discovery through

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesBiofilmsMicrobial Sensitivity TestsAnimalsAntimicrobial Cationic PeptidesColistinHumansMothsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesColistinantibiofilmantimicrobial peptideserum-stablesyntheticunnatural amino acids

Identifiers

PMID38712889
PMCPMC11185160

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.