ArticleeLife2024
Drift of neural ensembles driven by slow fluctuations of intrinsic excitability.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Statistics of cortical representational drift can enable robust readout.PLoS computational biology · 2026Article
- Distinct CA3 inputs differentially shape the learning-dependent evolution of right CA1 spatial maps.Nature communications · 2026Article
- Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps.bioRxiv : the preprint server for biology · 2025Article
- Three types of remapping with linear decoders: A population-geometric perspective.PLoS computational biology · 2025Article
- Article
- Three types of remapping with linear decoders: a population-geometric perspective.bioRxiv : the preprint server for biology · 2025Article
- Representational drift without synaptic plasticity.bioRxiv : the preprint server for biology · 2025Article
- Representational drift and learning-induced stabilization in the piriform cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Transcriptional determinants of goal-directed learning and representational drift in the parahippocampal cortex.Cell reports · 2025Article
- Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural ensembles: role of intrinsic excitability and its plasticity.Frontiers in cellular neuroscience · 2024Review
- Reward Expectation Reduces Representational Drift in the Hippocampus.bioRxiv : the preprint server for biology · 2023Article
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
4 authors.
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Abstract
Representational drift refers to the dynamic nature of neural representations in the brain despite the behavior being seemingly stable. Although drift has been observed in many different brain regions, the mechanisms underlying it are not known. Since intrinsic neural excitability is suggested to play a key role in regulating memory allocation, fluctuations of excitability could bias the reactivation of previously stored memory ensembles and therefore act as a motor for drift. Here, we propose a rate-based plastic recurrent neural network with slow fluctuations of intrinsic excitability. We first show that subsequent reactivations of a neural ensemble can lead to drift of this ensemble. The model predicts that drift is induced by co-activation of previously active neurons along with neurons with high excitability which leads to remodeling of the recurrent weights. Consistent with previous experimental works, the drifting ensemble is informative about its temporal history. Crucially, we show that the gradual nature of the drift is necessary for decoding temporal information from the activity of the ensemble. Finally, we show that the memory is preserved and can be decoded by an output neuron having plastic synapses with the main region.
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