Evidence map›Paper›PMID 38712759›Full record

ArticleCOPD2024

FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell Cytotoxicity.

Xiuying Li, Sowmya P Lakshmi, Kiyoshi Uemasu, Zachary Lane, Rajan T Reddy, Divay Chandra, Chunbin Zou, Yu Jiang, Toru Nyunoya

Abstract read
In one paragraph

Article in COPD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiuying LiDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Sowmya P LakshmiDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kiyoshi UemasuDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zachary LaneDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Rajan T ReddyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Divay ChandraDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Chunbin ZouDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Yu JiangDepartment of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Toru NyunoyaDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Funding

Role of FBXO24 mediated ubiquitination of FoxP1 protein in the pathogenesis and treatment of COPDR01HL153400 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHANDRA, DIVAY · 2020 to 2024
$2.3M
Epigenetic Modulation in Septic ImmunosuppressionR01HL142997 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZOU, CHUNBIN · 2019 to 2022
$1.8M
Role of TACC2 in smoking-induced COPDR01HL149719 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NYUNOYA, TORU · 2020 to 2023
$1.6M
Mechanisms of Signaling Protein Retention in the Primary CiliumR01GM132127 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JIANG, YU · 2019 to 2022
$1.3M
Role of smoking in severe influenza virus pneumoniaI01BX006096 · VA · VETERANS HEALTH ADMINISTRATION · PI Toru Nyunoya · 2024 to 2026
–
Role of DNA Repair in COPDI01CX001048 · VA · VETERANS HEALTH ADMINISTRATION · PI NYUNOYA, TORU · 2015 to 2017
–
Targeting F-box protein 048 in acute lung injuryI01CX000105 · VA · VETERANS HEALTH ADMINISTRATION · PI NYUNOYA, TORU · 2009 to 2022
–
BLRD VA I01 BX006096CSRD VA I01 CX000105CSRD VA I01 CX001048NHLBI NIH HHS R01 HL142997NHLBI NIH HHS R01 HL149719NHLBI NIH HHS R01 HL153400NIGMS NIH HHS R01 GM132127
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AMP-Activated Protein KinasesEpithelial CellsF-Box ProteinsProtein Serine-Threonine KinasesSmokeAMP-Activated Protein Kinase KinasesAnimalsCell LineCigarette SmokingCycloheximideHumansLeupeptinsMaleMiceMice, Inbred C57BLProteolysisAMP-Activated Protein Kinase KinasesAMP-Activated Protein Kinasesbenzyloxycarbonylleucyl-leucyl-leucine aldehydeCycloheximideF-Box ProteinsLeupeptinsProtein Serine-Threonine KinasesRNA, Small InterferingSmokeSTK11 protein, humanStk11 protein, mousebronchial airway epithelial cellschronic obstructive pulmonary diseasecigarette smokeFBXL19Serine-Threonine Kinase 11

Identifiers

PMID38712759
PMCPMC11186665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.