Evidence map›Paper›PMID 38712741›Full record

ArticleOncotarget2024

Deep learning-based whole-body PSMA PET/CT attenuation correction utilizing Pix-2-Pix GAN.

Kevin C Ma, Esther Mena, Liza Lindenberg, Nathan S Lay, Phillip Eclarinal, Deborah E Citrin, Peter A Pinto, Bradford J Wood, William L Dahut, James L Gulley and 4 more

Abstract read
In one paragraph

Article in Oncotarget, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Optimizing Attenuation Correction inDiagnostics (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kevin C MaArtificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Esther MenaMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Liza LindenbergMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nathan S LayArtificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Phillip EclarinalMolecular Imaging Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Deborah E CitrinRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Peter A PintoUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bradford J WoodCenter for Interventional Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
William L DahutGenitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
James L GulleyCenter for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ravi A MadanGenitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Peter L ChoykeArtificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ismail Baris TurkbeyArtificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Stephanie A HarmonArtificial Intelligence Resource, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Prostate Cancer ImagingZIABC010655 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$49.2M
Growth Factor Imaging and PhotoimmunotherapyZIABC010656 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2024
$31.6M
Cancer Therapy Clinical Trials Using Novel Recombinant VaccinesZIABC010666 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GULLEY, JAMES L. · 2009 to 2025
$22.4M
Center for Interventional OncologyZIDBC011242 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOOD, BRADFORD J · 2009 to 2025
$18.7M
Targeting mechanisms of radiation resistanceZIABC011552 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CITRIN, DEBORAH · 2014 to 2025
$12.2M
Instrumentation for microSPECT and microPET imagingZIABC010668 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2009 to 2025
$11.0M
CCR Artificial Intelligence ResourceZIHBC012032 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TÜRKBEY, BARIS · 2021 to 2025
$10.1M
Radiopharmaceutical Imaging and Therapy of CancerZIABC012167 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHOYKE, PETER L · 2024 to 2025
$3.9M
Natural History of Biochemically Recurrent Prostate CancerZIABC012118 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MADAN, RAVI · 2022 to 2025
$1.4M
Development of COVID-19 Imaging Tools with Artificial IntelligenceZIABC011936 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WOOD, BRADFORD J · 2020 to 2025
$1.2M
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
6 · The paper itself

Abstract

purposeSequential PET/CT studies oncology patients can undergo during their treatment follow-up course is limited by radiation dosage. We propose an artificial intelligence (AI) tool to produce attenuation-corrected PET (AC-PET) images from non-attenuation-corrected PET (NAC-PET) images to reduce need for low-dose CT scans.

methodsA deep learning algorithm based on 2D Pix-2-Pix generative adversarial network (GAN) architecture was developed from paired AC-PET and NAC-PET images.

resultsMedian NMSE, MAE, SSIM, and PSNR were 13.26%, 3.59%, 0.891, and 26.82, respectively, in the independent test cohort. ICC for SUV

conclusionThe Pix-2-Pix GAN model for generating AC-PET demonstrates SUV metrics that highly correlate with original images. AI-generated PET images show clinical potential for reducing the need for CT scans for attenuation correction while preserving quantitative markers and image quality.

Indexed as

Deep LearningPositron Emission Tomography Computed TomographyProstatic NeoplasmsAgedAlgorithmsAntigens, SurfaceGlutamate Carboxypeptidase IIHumansImage Processing, Computer-AssistedMaleMiddle AgedRadiopharmaceuticalsReproducibility of ResultsAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIRadiopharmaceuticalsattenuation correctiondeep learningPSMA PET

Identifiers

PMID38712741
PMCPMC11075367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.